Chen Chunqiu, Yu Zhen, Li Yongyu, Fichna Jakub, Storr Martin
Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Am J Chin Med. 2014;42(5):1053-70. doi: 10.1142/S0192415X14500669. Epub 2014 Sep 3.
Berberine is an isoquinoline alkaloid present in several plant species, including Coptis sp. and Berberis sp. In traditional medicine, extracts of berberine are used in the treatment of diarrhea of different origins. Recent studies have shown that berberine and its derivatives have significant biological effects on gastrointestinal (GI) and other functions and may become therapeutics for the treatment of diarrhea, gastroenteritis, diabetes, hyperlipidemia, cardiovascular diseases and inflammatory conditions. This paper summarizes the current knowledge on the actions of berberine in the GI tract. Binding and target sites, activated intracellular pathways, as well as the absorption and metabolism of berberine are discussed. Effects that may be useful in future clinical treatment, like antidiarrheal, anti-inflammatory and antitumor effects are critically reviewed and potential clinical applications are presented in detail.
黄连素是一种异喹啉生物碱，存在于多种植物中，包括黄连属植物和小檗属植物。在传统医学中，黄连素提取物用于治疗不同病因的腹泻。最近的研究表明，黄连素及其衍生物对胃肠道（GI）和其他功能具有显著的生物学作用，可能成为治疗腹泻、肠胃炎、糖尿病、高脂血症、心血管疾病和炎症性疾病的药物。本文总结了目前关于黄连素在胃肠道作用的知识。讨论了黄连素的结合和靶点、激活的细胞内途径以及吸收和代谢。对可能在未来临床治疗中有用的作用，如止泻、抗炎和抗肿瘤作用进行了严格审查，并详细介绍了潜在的临床应用。
