Diaz Michael J, Tran Jasmine T, Rose Drake, Wei Aria, Lakshmipathy Deepak, Lipner Shari R
College of Medicine, University of Florida, Gainesville, FL 32601, USA.
School of Medicine, Indiana University, Indianapolis, IN 46202, USA.
Nutrients. 2025 Jan 20;17(2):357. doi: 10.3390/nu17020357.
Vitiligo is a chronic autoimmune pigmentation disorder shaped by a complex interplay of genetic predispositions and environmental triggers. While conventional therapies-phototherapy, corticosteroids, and immunosuppressants-can be effective, their benefits are often partial and temporary, with recurrence common once treatment stops. As such, there is increasing interest in exploring complementary approaches that may offer a more sustainable impact. Emerging evidence suggests that macronutrient and micronutrient-level changes could be beneficial for managing progression and, in some cases, facilitating repigmentation. Antioxidant-rich foods, such as apples, green tea, Indian gooseberry, onions, and peppers, may help mitigate oxidative stress, while inflammatory foods, such as gluten and high-phenol nuts and berries, may exacerbate the condition. Certain supplements, including high-dose vitamin D, vitamin C, vitamin E, and selenium, may enhance phototherapy outcomes. Omega-3 and other unsaturated fatty acids, in addition to prebiotics and probiotics, are under active investigation for their roles in gut health and immune regulation. Notably, plant-derived compounds, i.e., , have demonstrated promise in promoting repigmentation and managing disease progression. However, it must be emphasized that these nutritional interventions remain exploratory, and more research is needed to establish their efficacy, safety, and optimal usage before they can be recommended as part of a standard treatment regimen.
白癜风是一种慢性自身免疫性色素沉着疾病，由遗传易感性和环境触发因素的复杂相互作用所形成。虽然传统疗法——光疗、皮质类固醇和免疫抑制剂——可能有效，但其益处往往是部分的且是暂时的，一旦治疗停止，复发很常见。因此，人们越来越有兴趣探索可能产生更可持续影响的补充方法。新出现的证据表明，常量营养素和微量营养素水平的变化可能有助于控制病情发展，在某些情况下还能促进色素再生。富含抗氧化剂的食物，如苹果、绿茶、印度醋栗、洋葱和辣椒，可能有助于减轻氧化应激，而炎症性食物，如麸质以及高酚类坚果和浆果，可能会加重病情。某些补充剂，包括高剂量维生素D、维生素C、维生素E和硒，可能会提高光疗效果。除了益生元和益生菌外，ω-3脂肪酸及其他不饱和脂肪酸因其在肠道健康和免疫调节中的作用正在积极研究中。值得注意的是，植物来源的化合物已显示出促进色素再生和控制疾病进展的前景。然而，必须强调的是，这些营养干预措施仍处于探索阶段，在它们能够被推荐作为标准治疗方案的一部分之前，还需要更多的研究来确定其疗效、安全性和最佳用法。
