谷胱甘肽 S-转移酶 M1 基因缺失型与冠心病风险的关联：一项荟萃分析。
Association between GSTM1 null genotype and coronary artery disease risk: a meta-analysis.
作者信息
Yang Mei, Zhao Jing, Xing Lin, Shi Li
机构信息
Intensive Care Unit, Jinan Third People's Hospital, Jinan, China (mainland).
Department of Cardiology, Provincial Hospital Affiliated to Shandong University, Jinan, China (mainland).
出版信息
Med Sci Monit. 2014 Sep 1;20:1550-5. doi: 10.12659/MSM.890876.
BACKGROUND
We conducted a meta-analysis to assess the association between polymorphisms of GSTM1 null genotype and coronary artery disease (CAD) risk.
MATERIAL AND METHODS
Published literature from PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) were retrieved before March 2014. All studies reporting adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of CAD risk were included.
RESULTS
A total of 13 case-control studies, including 5453 cases and 5068 controls, were collected. There was a significant association between GSTM1 null genotype and CAD risk (adjusted OR=1.26; 95% CI, 1.11-1.43; I^2=3%). When stratified by ethnicity, a significantly elevated risk was observed in whites. In the subgroup analysis according to disease type, a significantly increased myocardial infarction (MI) risk was observed. Subgroup analysis of smoking status showed an increased CAD risk in smokers.
CONCLUSIONS
Our results indicate that GSTM1 null genotype is associated with an increased CAD risk.
背景
我们进行了一项荟萃分析，以评估谷胱甘肽S转移酶M1（GSTM1）基因缺失多态性与冠状动脉疾病（CAD）风险之间的关联。
材料与方法
检索了截至2014年3月来自PubMed、EMBASE和中国知网（CNKI）的已发表文献。纳入所有报告CAD风险调整比值比（OR）和95%置信区间（CI）的研究。
结果
共收集了13项病例对照研究，包括5453例病例和5068例对照。GSTM1基因缺失多态性与CAD风险之间存在显著关联（调整OR = 1.26；95% CI，1.11 - 1.43；I² = 3%）。按种族分层时，白人中观察到风险显著升高。在按疾病类型进行的亚组分析中，心肌梗死（MI）风险显著增加。吸烟状况的亚组分析显示吸烟者CAD风险增加。
结论
我们的结果表明，GSTM1基因缺失多态性与CAD风险增加有关。
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