Gu Jianchun, Zou Hanqing, Zheng Leizhen, Li Xiaoping, Chen Siyu, Zhang Li
Department of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai, 200092, China.
Tumour Biol. 2014 Apr;35(4):3439-45. doi: 10.1007/s13277-013-1454-z. Epub 2013 Dec 8.
Previous studies have suggested that the glutathione S-transferases M1 (GSTM1) null genotype is associated with the risk of gastric cancer. However, the interaction between GSTM1 null genotype and smoking for the risk of gastric cancer is still elusive. Therefore, we performed a meta-analysis to ascertain this issue. Databases of PubMed, EMBASE, and China National Knowledge Infrastructure were searched to retrieve relevant studies. Smokers were categorized as "ever-smokers" and "non-smokers." Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to estimate the association strength. Subgroup analyses according to ethnicity, source of control, and sample size were also conducted. A total of 15 eligible studies, including 4,687 gastric cancer cases and 7,002 controls, were identified. We found that the GSTM1 null genotype was associated with increased risk of gastric cancer among ever-smokers (OR = 1.460, 95% CI 1.064-2.003, heterogeneity: P = 0.019). The null genotype also significantly increased the risk of gastric cancer among non-smokers (OR = 1.777, 95% CI 1.301-2.426, heterogeneity: P < 0.01). Stratified analysis according to ethnicity showed that the GSTM1 null genotype was associated with increased risk of gastric cancer among Asians both in ever-smokers (OR = 1.841, 95% CI 1.184-2.861) and non-smokers (OR = 1.773, 95% CI 1.382-2.275). In conclusion, the GSMT1 null genotype significantly increased the risk of gastric cancer both in ever-smokers and non-smokers.
以往研究表明，谷胱甘肽S-转移酶M1（GSTM1）基因缺失型与胃癌风险相关。然而，GSTM1基因缺失型与吸烟对胃癌风险的相互作用仍不明确。因此，我们进行了一项荟萃分析以确定这一问题。检索了PubMed、EMBASE和中国知网数据库以获取相关研究。吸烟者被分为“曾经吸烟者”和“从不吸烟者”。计算比值比（OR）和95%置信区间（95%CI）以估计关联强度。还根据种族、对照来源和样本量进行了亚组分析。共纳入15项符合条件的研究，包括4687例胃癌病例和7002例对照。我们发现，在曾经吸烟者中，GSTM1基因缺失型与胃癌风险增加相关（OR = 1.460，95%CI 1.064 - 2.003，异质性：P = 0.019）。该基因缺失型在从不吸烟者中也显著增加了胃癌风险（OR = 1.777，95%CI 1.301 - 2.426，异质性：P < 0.01）。根据种族进行的分层分析表明，在亚洲人中，无论曾经吸烟者（OR = 1.841，95%CI 1.184 - 2.861）还是从不吸烟者（OR = 1.773，95%CI 1.382 - 2.275），GSTM1基因缺失型均与胃癌风险增加相关。总之，GSTM1基因缺失型在曾经吸烟者和从不吸烟者中均显著增加了胃癌风险。
