Department of Scientific Research, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China.
Department of Hospital Infection Control, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China.
J Int Med Res. 2022 Sep;50(9):3000605221123697. doi: 10.1177/03000605221123697.
To undertake a meta-analysis to investigate if there is an association between the glutathione S-transferase mu 1 () gene polymorphism, coronary artery disease (CAD) susceptibility and smoking.
Electronic databases, including PubMed®, Web of Science and Embase®, were searched for relevant case-control studies. Data were extracted and the odds ratio (OR) was calculated and appropriate statistical methods were used for the meta-analysis.
The analysis included eight studies with a total of 1880 cases with CAD and 1758 control subjects. The results of this meta-analysis demonstrated that there is no association between the null and CAD (OR 1.24, 95% confidence interval [CI] 1.00, 1.55). An increased risk of CAD was observed in the smoking population with the null genotype (OR 1.48, 95% CI 1.02, 2.15). Subgroup analyses of geographical region, genotyping method and publication language category demonstrated potential relationships among gene polymorphism, smoking and CAD.
Based on the current literature, the null genotype was associated to CAD in the smoking population. The interaction between smoking and polymorphism may contribute to the susceptibility of CAD.
进行荟萃分析，以调查谷胱甘肽 S-转移酶 mu 1（）基因多态性与冠心病（CAD）易感性和吸烟之间是否存在关联。
检索电子数据库，包括 PubMed®、Web of Science 和 Embase®，以查找相关的病例对照研究。提取数据并计算比值比（OR），并使用适当的统计方法进行荟萃分析。
该分析包括 8 项研究，共有 1880 例 CAD 患者和 1758 例对照。荟萃分析的结果表明，与 CAD 之间没有关联（OR 1.24，95%置信区间 [CI] 1.00，1.55）。在携带 null 基因型的吸烟人群中，观察到 CAD 的风险增加（OR 1.48，95%CI 1.02，2.15）。地理区域、基因分型方法和出版语言类别的亚组分析表明，基因多态性、吸烟和 CAD 之间存在潜在关系。
根据目前的文献，在吸烟人群中，null 基因型与 CAD 相关。吸烟和 多态性之间的相互作用可能导致 CAD 的易感性。
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