Sannita W G, Gervasio L, Zagnoni P
Institute of Neurophysiopathology, University, Genova, Italy.
Neuropsychobiology. 1989;22(4):231-5. doi: 10.1159/000118622.
The quantitative background EEG effects (power spectral analysis) and plasma concentration of sodium valproate were studied after acute single-dose administration and during long-term single-drug treatment, in 10 previously untreated epileptic patients with generalized nonconvulsive seizures. A transient decrease of the signal amplitude (preponderant on anterior scalp areas) and of the 12.5 to 45.0-Hz relative power (limited to the posterior electrode derivations) was observed during the first weeks of chronic treatment. These EEG effects were not correlated with the drug plasma concentration levels or with the occurrence of behavioral side effects (e.g. drowsiness), while being concomitant with the reduction of specific epileptic EEG phenomena. Opposite trends of variation were observed after single-dose acute administration, though with limited statistical significance across subjects.
对10例既往未经治疗的全身性非惊厥性癫痫患者进行了急性单剂量给药后以及长期单药治疗期间丙戊酸钠的定量背景脑电图效应（功率谱分析）和血浆浓度研究。在慢性治疗的最初几周内，观察到信号幅度（主要在前头部头皮区域）和12.5至45.0赫兹相对功率（仅限于后电极导联）出现短暂下降。这些脑电图效应与药物血浆浓度水平或行为副作用（如嗜睡）的发生无关，同时伴有特定癫痫性脑电图现象的减少。单剂量急性给药后观察到相反的变化趋势，尽管在受试者中统计学意义有限。
