Eskandarani Hassan Ali, Kehrer Michala, Christensen Peer Brehm
Department of Infectious Diseases Q, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.
Dan Med J. 2014 Sep;61(9):A4907.
Exposure to blood and body fluids (BBF) is a major concern for health-care workers (HCWs) and implies a risk of infection with blood-borne pathogens. However, in Denmark, no exposure incidence studies among HCWs have been reported for the past ten years. The aims of this study were to provide an updated evaluation of the annual frequency of registered exposures during the 2003-2012 period, the prevalence and incidence of transmission of HIV, HBV and HCV among HCWs, the prevalence of HIV, HBV and HCV among source patients, the follow-up by HBV vaccination and blood sampling in exposed HCWs and, finally, reporting habits.
All registered first-time cases of BBF exposure at Odense University Hospital during the 2003-2012 period were included. The exposed HCW and source patient were linked to a laboratory database to obtain the test results for HIV, HBV, HCV and the anti-HBs level at baseline and after exposure. For 2012, a detailed analysis of BBF exposure was performed.
A total of 2,274 first-time BBF exposures were analysed. We observed a 35% increase in the reported incidence of exposures in the period. The prevalence and incidence of HIV, HBV and HCV among HCWs was zero. The prevalence of anti-HIV among source patients was 0.9%, HBsAg 1.2% and anti-HCV/HCV-RNA 3.8%. In 2003-2012, 31.3% of the tested HCWs had an anti-HBs ≥ 10 IU/l at baseline and this increased to 76.1% after vaccination. In 2012, 95% of the HCWs had blood samples at the time of exposure, 35% had a three-month blood test and 17% had a six-month test.
Despite a high rate of exposure to BBF among HCWs, the risk of infection was low.
no external funding received.
not relevant.
接触血液和体液（BBF）是医护人员（HCW）主要关注的问题，这意味着存在感染血源性病原体的风险。然而，在丹麦，过去十年间尚未有关于医护人员接触发生率的研究报告。本研究的目的是对2003年至2012年期间登记的接触事件的年度发生率进行更新评估，了解医护人员中HIV、HBV和HCV传播的患病率和发病率，源患者中HIV、HBV和HCV的患病率，对接触后的医护人员进行乙肝疫苗接种和血液采样的随访情况，以及最后的报告习惯。
纳入2003年至2012年期间在欧登塞大学医院登记的所有首次BBF接触病例。将接触的医护人员和源患者与实验室数据库关联，以获取HIV、HBV、HCV的检测结果以及基线和接触后的抗-HBs水平。针对2012年，对BBF接触情况进行了详细分析。
共分析了2274例首次BBF接触事件。我们观察到该期间报告的接触发生率增加了35%。医护人员中HIV、HBV和HCV的患病率和发病率为零。源患者中抗-HIV的患病率为0.9%，HBsAg为1.2%，抗-HCV/HCV-RNA为3.8%。在2003年至2012年期间，31.3%接受检测的医护人员基线时抗-HBs≥10 IU/l，接种疫苗后这一比例增至76.1%。2012年，95%的医护人员在接触时采集了血样，35%进行了三个月的血液检测，17%进行了六个月的检测。
尽管医护人员接触BBF的发生率较高，但感染风险较低。
未获得外部资金。
不相关。
