Gomes N das G, Pereira F E
Departamento de Patologia Centro Biomédico, Universidade Federal do Espírito Santo.
Rev Soc Bras Med Trop. 1989 Oct-Dec;22(4):191-7.
The effect of chronic ethyl alcohol intoxication on the evolution of Trypanosoma cruzi infection in mice was studied by two experimental procedures: (1) mice after 60 days of infection with a myotropic strain of T. cruzi were submitted to chronic alcoholic intoxidation receiving a 7% ethanol solution as only liquid source for six months; (2) mice chronically intoxicated with ethanol during five months were infected with the same strain of T. cruzi and were followed up for 45 days drinking the 7% alcoholic solution. In comparison with the infected group, not treated with ethanol, the infected mice that received the ethanol showed: a) similar mortality in the two experiments; (b) higher parasitemia in the acute phase and more frequent blood parasites in the chronic phase; (c) myocarditis with less severe cellular exudation but with increased fibrosis; (d) in the skeletal muscle, milder myositis and low frequency of arteritis and hyaline thrombi.
（1）用亲肌性克氏锥虫株感染60天后的小鼠接受慢性酒精中毒，以7%乙醇溶液作为唯一液体来源，持续6个月；（2）在5个月内慢性乙醇中毒的小鼠感染同一株克氏锥虫，并饮用7%酒精溶液随访45天。与未用乙醇处理的感染组相比，接受乙醇的感染小鼠表现出：a）在两个实验中死亡率相似；b）急性期寄生虫血症较高，慢性期血液寄生虫更频繁；c）心肌炎，细胞渗出较轻但纤维化增加；d）在骨骼肌中，肌炎较轻，动脉炎和透明血栓的发生率较低。
