多发性硬化症患者脑脊液和血清中IgG、IgA及IgM的κ/λ比值

Kappa/lambda ratios in IgG, IgA and IgM of cerebrospinal fluid and of sera in patients with multiple sclerosis.

作者信息

Araga S, Kagimoto H, Wada A, Funamoto K, Inoue K, Takahashi K

机构信息

Division of Neurology, Institute of Neurological Sciences, Tottori University School of Medicine, Yonago, Japan.

出版信息

Autoimmunity. 1989;5(1-2):133-7. doi: 10.3109/08916938909029151.

DOI:10.3109/08916938909029151

PMID:2519013

Abstract

Kappa/lambda (kappa/lambda) ratios of each immunoglobulin, i.e. IgG, IgA and IgM in cerebrospinal fluid (CSF) and in sera of patients with multiple sclerosis (MS) were analysed by sandwich enzyme linked immunosorbent assay. In CSF kappa/lambda ratios of IgG of MS patients were significantly (p less than 0.05) higher than those of normal controls, whereas the values of IgA and IgM did not differ significantly from those of normal controls. In sera kappa/lambda ratios of IgG, IgA and IgM did not differ significantly from those of normal controls. Our results suggest that in MS patients abnormal kappa/lambda ratios are also restricted to IgG components in CSF, as oligoclonal IgG bands are.

摘要

采用夹心酶联免疫吸附测定法分析了多发性硬化症（MS）患者脑脊液（CSF）和血清中各免疫球蛋白（即IgG、IgA和IgM）的κ/λ（kappa/lambda）比值。在脑脊液中，MS患者IgG的κ/λ比值显著高于正常对照组（p<0.05），而IgA和IgM的值与正常对照组无显著差异。在血清中，IgG、IgA和IgM的κ/λ比值与正常对照组无显著差异。我们的结果表明，在MS患者中，异常的κ/λ比值也像寡克隆IgG带一样，仅限于脑脊液中的IgG成分。