Nayeem Sarmah B, Arfuso Frank, Dharmarajan Arun, Keelan Jeffrey A
School of Women's and Infant's Health, University of Western Australia, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, WA 6008, Australia.
School of Anatomy, Physiology and Human Biology, Faculty of Science, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
Reprod Fertil Dev. 2016 Apr;28(5):525-44. doi: 10.1071/RD14079.
The integration of a complex network of signalling molecules promotes implantation of the blastocyst and development of the placenta. These processes are crucial for a successful pregnancy and fetal growth and development. The signalling network involves both cell-cell and cell-extracellular matrix communication. The family of secreted glycoprotein ligands, the Wnts, plays a major role in regulating a wide range of biological processes, including embryonic development, cell fate, proliferation, migration, stem cell maintenance, tumour suppression, oncogenesis and tissue homeostasis. Recent studies have provided evidence that Wnt signalling pathways play an important role in reproductive tissues and in early pregnancy events. The focus of this review is to summarise our present knowledge of expression, regulation and function of the Wnt signalling pathways in early pregnancy events of human and other model systems, and its association with pathological conditions. Despite our recent progress, much remains to be learned about Wnt signalling in human reproduction. The advancement of knowledge in this area has applications in the reduction of infertility and the incidence and morbidity of gestational diseases.
复杂信号分子网络的整合促进了囊胚着床和胎盘发育。这些过程对于成功怀孕以及胎儿生长发育至关重要。信号网络涉及细胞间和细胞与细胞外基质的通讯。分泌型糖蛋白配体家族Wnts在调节广泛的生物学过程中起主要作用，包括胚胎发育、细胞命运、增殖、迁移、干细胞维持、肿瘤抑制、肿瘤发生和组织稳态。最近的研究提供了证据表明Wnt信号通路在生殖组织和早期妊娠事件中起重要作用。本综述的重点是总结我们目前对人类和其他模型系统早期妊娠事件中Wnt信号通路的表达、调节和功能及其与病理状况的关联的认识。尽管我们最近取得了进展，但关于Wnt信号在人类生殖中的作用仍有许多有待了解。该领域知识的进步在降低不孕症以及妊娠疾病的发生率和发病率方面具有应用价值。
