Hui Annie S Y, Lao Terence T, Leung Tak Yeung, Schaaf Jelle M, Sahota Daljit S
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region.
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region.
Int J Gynaecol Obstet. 2014 Dec;127(3):248-53. doi: 10.1016/j.ijgo.2014.06.019. Epub 2014 Aug 10.
To examine trends in preterm birth and its relationship with perinatal mortality in Hong Kong.
In a retrospective cohort study, data were reviewed from singletons delivered between 1995 and 2011 at a university teaching hospital. Trends in preterm birth (between 24 and 36 weeks of pregnancy), perinatal mortality, and subtypes of preterm birth (spontaneous, iatrogenic, and following preterm premature rupture of membranes [PPROM]) were examined via linear regression.
There were 103 364 singleton deliveries, of which 6722 (6.5%) occurred preterm, including 1835 (1.8%) early preterm births (24-33 weeks) and 4887 (4.7%) late preterm births (34-36 weeks). Frequency of preterm birth remained fairly consistent over the study period, but that of spontaneous preterm birth decreased by 25% (β=-0.83; P<0.001), from 4.5% to 3.8%. Frequency of preterm birth following PPROM increased by 135% (β=0.82; P<0.001), from 0.7% to 1.7%. The perinatal mortality rate decreased from 56.7 to 37.0 deaths per 1000 deliveries before 37 weeks (β=-0.16; P=0.54). Early preterm birth contributed to 16.0% of all deaths.
Although the overall rate of preterm birth in Hong Kong has remained constant, the frequencies of its subtypes have changed. Overall perinatal mortality is gradually decreasing, but early preterm birth remains a major contributor.
研究香港早产的趋势及其与围产期死亡率的关系。
在一项回顾性队列研究中，对1995年至2011年在一所大学教学医院分娩的单胎数据进行了回顾。通过线性回归分析了早产（妊娠24至36周）、围产期死亡率及早产亚型（自发性、医源性和胎膜早破后早产[PPROM]）的趋势。
共有103364例单胎分娩，其中6722例（6.5%）为早产，包括1835例（1.8%）早期早产（24至33周）和4887例（4.7%）晚期早产（34至36周）。在研究期间，早产的发生率保持相当稳定，但自发性早产的发生率下降了25%（β=-0.83；P<0.001），从4.5%降至3.8%。PPROM后早产的发生率增加了135%（β=0.82；P<0.001），从0.7%升至1.7%。围产期死亡率从每1000例37周前分娩中的56.7例死亡降至37.0例（β=-0.16；P=0.54）。早期早产占所有死亡病例的16.0%。
虽然香港早产的总体发生率保持不变，但其亚型的发生率发生了变化。围产期总体死亡率在逐渐下降，但早期早产仍是主要死因。
