Chow Prudence P C, Yip Wilson W K, Ho Mary, Lok Julie Y C, Lau Henry H W, Young Alvin L
Department of Ophthalmology and Visual Sciences, 1/F Eye Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.
Int Ophthalmol. 2019 Apr;39(4):903-909. doi: 10.1007/s10792-018-0896-0. Epub 2018 Jun 16.
To describe and evaluate the trends in the incidence of retinopathy of prematurity over a 10-year period in a tertiary hospital in Hong Kong.
A retrospective review was performed on all preterm infants screened and/or treated for retinopathy of prematurity from January 2006 to December 2015 at Prince of Wales Hospital, Hong Kong. Preterm infants with incomplete records or transferred-in from other hospitals/region solely for treatment of ROP were excluded. The incidence of any ROP or Type 1 ROP was analysed with gestational age and birth weight over a 10-year period with consecutive 2-year intervals to evaluate the trends.
Of all 754 infants included in the study, 234 (31.0%) patients had any ROP and 34 (4.5%) infants developed Type 1 ROP. The incidence of any ROP demonstrated a statistically significant decreasing trend over the five consecutive 2-year intervals (p = 0.016), but the incidence trend of Type 1 ROP is not statistically significant. No infants weighing more than 1250 g developed Type 1 ROP.
We observed a decreasing trend in the incidence of any ROP across the 10-year period in a tertiary hospital in Hong Kong, while the incidence of Type 1 ROP remained stable at 4.5%. The factors leading to the trend were unclear. Improved prenatal care, changing proportion of cases with different birth weight and gestational age, oxygenation level practice in neonatal unit may all contribute to the decreasing trend. Revision of screening criteria may be made according to local experience to maximise cost-effectiveness.
描述并评估香港一家三级医院10年期内早产儿视网膜病变的发病率趋势。
对2006年1月至2015年12月在香港威尔士亲王医院接受早产儿视网膜病变筛查和/或治疗的所有早产儿进行回顾性研究。排除记录不完整或仅为治疗早产儿视网膜病变而从其他医院/地区转入的早产儿。分析10年期内按胎龄和出生体重划分的任何早产儿视网膜病变或1型早产儿视网膜病变的发病率，以连续2年为间隔评估趋势。
在纳入研究的所有754例婴儿中，234例（31.0%）患有任何早产儿视网膜病变，34例（4.5%）婴儿发生1型早产儿视网膜病变。在连续5个2年间隔中，任何早产儿视网膜病变的发病率呈现出统计学上显著的下降趋势（p = 0.016），但1型早产儿视网膜病变的发病率趋势无统计学意义。体重超过1250 g的婴儿均未发生1型早产儿视网膜病变。
我们观察到香港一家三级医院在10年期内任何早产儿视网膜病变的发病率呈下降趋势，而1型早产儿视网膜病变的发病率稳定在4.5%。导致该趋势的因素尚不清楚。改善产前护理、不同出生体重和胎龄病例比例的变化、新生儿病房的氧合水平实践可能都促成了下降趋势。可根据当地经验修订筛查标准以实现成本效益最大化。
