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本文引用的文献

1
Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.赖氨酸特异性去甲基化酶 1 调节滋养层干细胞的分化起始和迁移。
Nat Commun. 2014;5:3174. doi: 10.1038/ncomms4174.
2
The FOS transcription factor family differentially controls trophoblast migration and invasion.FOS 转录因子家族差异调控滋养层细胞的迁移和侵袭。
J Biol Chem. 2014 Feb 21;289(8):5025-39. doi: 10.1074/jbc.M113.523746. Epub 2013 Dec 30.
3
c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface.c-Met 依赖性多能迷路滋养层祖细胞建立胎盘交换界面。
Dev Cell. 2013 Nov 25;27(4):373-86. doi: 10.1016/j.devcel.2013.10.019.
4
Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.单细胞表观遗传修饰因子分析鉴定 PRDM14 为哺乳动物胚胎细胞命运的诱导因子。
Cell Rep. 2013 Nov 14;5(3):687-701. doi: 10.1016/j.celrep.2013.09.044. Epub 2013 Oct 31.
5
Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells.Sox2 调控网络的上下文相关连接，用于胚胎干细胞和滋养层干细胞的自我更新。
Mol Cell. 2013 Nov 7;52(3):380-92. doi: 10.1016/j.molcel.2013.09.002. Epub 2013 Oct 10.
6
Transcriptional reprogramming and chromatin remodeling accompanies Oct4 and Nanog silencing in mouse trophoblast lineage.在小鼠滋养层细胞系中，转录重编程和染色质重塑伴随着Oct4和Nanog的沉默。
Stem Cells Dev. 2014 Feb 1;23(3):219-29. doi: 10.1089/scd.2013.0328. Epub 2013 Nov 7.
7
The transcriptional co-repressor TLE3 regulates development of trophoblast giant cells lining maternal blood spaces in the mouse placenta.转录共抑制因子 TLE3 调节小鼠胎盘内衬有母体血液腔的滋养层巨细胞的发育。
Dev Biol. 2013 Oct 1;382(1):1-14. doi: 10.1016/j.ydbio.2013.08.005. Epub 2013 Aug 16.
8
Genomic vagabonds: endogenous retroviruses and placental evolution.
Bioessays. 2013 Oct;35(10):845-6. doi: 10.1002/bies.201300099. Epub 2013 Aug 12.
9
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells.单细胞 RNA 测序分析人类着床前胚胎和胚胎干细胞。
Nat Struct Mol Biol. 2013 Sep;20(9):1131-9. doi: 10.1038/nsmb.2660. Epub 2013 Aug 11.
10
Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms.血管生成素通过 Hippo 通路依赖和非依赖机制防止小鼠胚胎多能谱系分化。
Nat Commun. 2013;4:2251. doi: 10.1038/ncomms3251.

具有血绒毛膜胎盘的哺乳动物中滋养层谱系的转录调节因子。

Transcriptional regulators of the trophoblast lineage in mammals with hemochorial placentation.

作者信息

Knott Jason G, Paul Soumen

机构信息

Developmental Epigenetics LaboratoryDepartment of Animal Science, Michigan State University, East Lansing, Michigan 48824, USADepartment of Pathology and Laboratory MedicineInstitute of Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.

Developmental Epigenetics LaboratoryDepartment of Animal Science, Michigan State University, East Lansing, Michigan 48824, USADepartment of Pathology and Laboratory MedicineInstitute of Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA

出版信息

Reproduction. 2014 Dec;148(6):R121-36. doi: 10.1530/REP-14-0072. Epub 2014 Sep 4.

DOI:10.1530/REP-14-0072
PMID:25190503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4231008/
Abstract

Mammalian reproduction is critically dependent on the trophoblast cell lineage, which assures proper establishment of maternal-fetal interactions during pregnancy. Specification of trophoblast cell lineage begins with the development of the trophectoderm (TE) in preimplantation embryos. Subsequently, other trophoblast cell types arise with the progression of pregnancy. Studies with transgenic animal models as well as trophoblast stem/progenitor cells have implicated distinct transcriptional and epigenetic regulators in trophoblast lineage development. This review focuses on our current understanding of transcriptional and epigenetic mechanisms regulating specification, determination, maintenance and differentiation of trophoblast cells.

摘要

哺乳动物的繁殖严重依赖于滋养层细胞谱系，该谱系可确保孕期母胎相互作用的正常建立。滋养层细胞谱系的特化始于植入前胚胎中滋养外胚层（TE）的发育。随后，随着孕期的进展会出现其他类型的滋养层细胞。对转基因动物模型以及滋养层干/祖细胞的研究表明，不同的转录和表观遗传调节因子参与了滋养层谱系的发育。本综述重点阐述了我们目前对调节滋养层细胞特化、决定、维持和分化的转录及表观遗传机制的理解。