Douglas Gordon C, VandeVoort Catherine A, Kumar Priyadarsini, Chang Tien-Cheng, Golos Thaddeus G
Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715-1299, USA.
Endocr Rev. 2009 May;30(3):228-40. doi: 10.1210/er.2009-0001. Epub 2009 Mar 18.
The placenta is an ephemeral organ containing diverse populations of trophoblasts that are all derived from the embryonic trophectoderm but have morphological, functional, and molecular diversity within and across species. In hemochorial placentation, these cells play especially important roles, interfacing with and modifying the cells of the maternal decidua. Within the rapidly growing placenta, it has been shown that there are trophoblast stem cells well characterized in the mouse and postulated but not well understood in primates. This review will discuss the characteristics of candidates for human and nonhuman primate trophoblast stem cells, present the diverse methods of their generation, and propose future prospects for experimental systems in which they can shed light on developmental and pathophysiological processes in human pregnancy.
胎盘是一个临时性器官，包含多种滋养层细胞群体，这些细胞均来源于胚胎滋养外胚层，但在种内和种间具有形态、功能及分子多样性。在血绒毛膜胎盘形成过程中，这些细胞发挥着尤为重要的作用，与母体蜕膜细胞相互作用并对其进行修饰。在快速生长的胎盘内，已证实小鼠体内存在特征明确的滋养层干细胞，灵长类动物中也推测有此类细胞，但尚未完全了解。本综述将讨论人类和非人灵长类动物滋养层干细胞候选细胞的特征，介绍其多种生成方法，并提出未来实验系统的前景，通过这些系统，它们可揭示人类妊娠中的发育和病理生理过程。
