绿色电化学传感平台：利用源自天然鱼鳞的羟基磷灰石作为一种新型电化学材料用于灵敏检测肾损伤分子1（KIM-1）。
Green electrochemical sensing platforms: utilizing hydroxyapatite derived from natural fish scales as a novel electrochemical material for the sensitive detection of kidney injury molecule 1 (KIM-1).
作者信息
Zhang Ying, Zhang Wei, Zhang Qing, Li Kaiyang, Liu Wei, Liu Yong, Banks Craig E
机构信息
National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P.R. China.
出版信息
Analyst. 2014 Nov 7;139(21):5362-6. doi: 10.1039/c4an00957f.
Urinary KIM-1 is an ideal biomarker for acute kidney injury diagnosis. The proof-of-concept is demonstrated by utilizing the hydroxyapatite derived from natural fish scales as an electrode material, where the sensing of KIM-1 is shown to be possible for the first time with a linear range from 0.01 to 0.20 μg mL(-1) and a detection limit of 0.017 μg mL(-1) under model conditions; proof-of-concept is demonstrated in spiked urine.
尿肾损伤分子-1（KIM-1）是急性肾损伤诊断的理想生物标志物。通过使用天然鱼鳞衍生的羟基磷灰石作为电极材料，证明了其概念验证，在模型条件下首次表明能够检测KIM-1，线性范围为0.01至0.20μg mL⁻¹，检测限为0.017μg mL⁻¹；在加标的尿液中也证明了概念验证。
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