Honjo H, Urabe M, Naitoh K, Ogino Y, Kitawaki J, Yasuda J, Yamamoto T, Okada H
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Japan.
Hum Cell. 1989 Sep;2(3):254-9.
Estrone sulfate (E1-S) has been shown to be quantitatively the most important estrogen in peripheral blood. But, the physiological and/or pathological role of E1-S is not yet clarified. At present, we tried to clarify it using tissue cultures. In tissue cultures of human endometrium, secretory endometrium showed higher activity of estrone sulfatase (E1----E1-S) than proliferative endometrium. Progesterone added in the medium induced an increase of estrone sulfotransferase in the proliferative endometrium. The results suggest a reducing effect of estrogen by progesterone in secretory endometrium in physiological conditions. Estrogen dependent malignant tumors (breast cancer, endometrial cancer) have high estrone sulfatase. It converts E1-S to E1 (----E2) which are abundant in these tumors. Ishikawa cell line increased estrone sulfotransferase activity with progesterone, somewhat like the physiological conditions. From out study in vivo, there is a possibility of some ameliorative effects of E1-S on the central nervous system of patients with senile dementia (Alzheimer's type). Effects of E1-S on central nerves were investigated using tissue cultures.
硫酸雌酮（E1-S）已被证明是外周血中数量上最重要的雌激素。但是，E1-S的生理和/或病理作用尚未阐明。目前，我们试图通过组织培养来阐明这一点。在人子宫内膜的组织培养中，分泌期子宫内膜显示出比增殖期子宫内膜更高的硫酸雌酮酶（E1→E1-S）活性。培养基中添加的孕酮可诱导增殖期子宫内膜中硫酸雌酮转移酶增加。结果表明，在生理条件下，孕酮对分泌期子宫内膜中的雌激素有降低作用。雌激素依赖性恶性肿瘤（乳腺癌、子宫内膜癌）具有高硫酸雌酮酶。它将E1-S转化为E1（→E2），而这些物质在这些肿瘤中含量丰富。石川细胞系在孕酮作用下硫酸雌酮转移酶活性增加，有点类似于生理条件。根据我们的体内研究，E1-S对老年痴呆（阿尔茨海默型）患者的中枢神经系统有一些改善作用的可能性。使用组织培养研究了E1-S对中枢神经的作用。
