造血过程中的微小RNA

microRNAs in hematopoiesis.

作者信息

Lazare Seka S, Wojtowicz Edyta E, Bystrykh Leonid V, de Haan Gerald

机构信息

Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.

出版信息

Exp Cell Res. 2014 Dec 10;329(2):234-8. doi: 10.1016/j.yexcr.2014.08.033. Epub 2014 Sep 3.

DOI:10.1016/j.yexcr.2014.08.033

PMID:25192911

Abstract

miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood cells. Regulation by miRNAs is markedly intertwined with transcription factors. In this review, we highlight miRNAs shown to be important for HSC maintenance and lineage differentiation with focus on their interaction with transcription factors. We also pay attention to the diverse modes of miRNA regulation.

摘要

微小RNA（miRNA）参与了造血作用的各个阶段，包括维持造血干细胞（HSC）的自我更新以及分化为成熟血细胞。miRNA的调控与转录因子显著交织在一起。在本综述中，我们重点介绍了对HSC维持和谱系分化很重要的miRNA，着重关注它们与转录因子的相互作用。我们还关注miRNA调控的多种模式。