Shree Nitya, Ding Zehuan, Flaws Jodi, Choudhury Mahua
Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University (TAMU), College Station, TX 77843, USA.
Department of Comparative Biosciences, University of Illinois Urbana-Champaign, Urbana, IL 61802, USA.
Metabolites. 2022 Oct 28;12(11):1034. doi: 10.3390/metabo12111034.
The prevalence of poor metabolic health is growing exponentially worldwide. This condition is associated with complex comorbidities that lead to a compromised quality of life. One of the contributing factors recently gaining attention is exposure to environmental chemicals, such as endocrine-disrupting chemicals (EDCs). Considerable evidence suggests that EDCs can alter the endocrine system through immunomodulation. More concerning, EDC exposure during the fetal development stage has prominent adverse effects later in life, which may pass on to subsequent generations. Although the mechanism of action for this phenomenon is mostly unexplored, recent reports implicate that non-coding RNAs, such as microRNAs (miRs), may play a vital role in this scenario. MiRs are significant contributors in post-transcriptional regulation of gene expression. Studies demonstrating the immunomodulation of EDCs via miRs in metabolic health or towards the Developmental Origins of Health and Disease (DOHaD) Hypothesis are still deficient. The aim of the current review was to focus on studies that demonstrate the impact of EDCs primarily on innate immunity and the potential role of miRs in metabolic health.
全球范围内，代谢健康状况不佳的患病率正呈指数级增长。这种状况与复杂的合并症相关，会导致生活质量下降。最近受到关注的一个促成因素是接触环境化学物质，如内分泌干扰化学物质（EDC）。大量证据表明，EDC可通过免疫调节改变内分泌系统。更令人担忧的是，胎儿发育阶段接触EDC在日后生活中会产生显著的不良影响，且这种影响可能会遗传给后代。尽管这一现象的作用机制大多尚未明确，但最近的报告表明，非编码RNA，如微小RNA（miR），可能在这一过程中发挥重要作用。miR是基因表达转录后调控的重要贡献者。关于通过miR在代谢健康方面或针对健康与疾病的发育起源（DOHaD）假说对EDC进行免疫调节的研究仍然不足。本综述的目的是聚焦于那些证明EDC主要对先天免疫的影响以及miR在代谢健康中的潜在作用的研究。
