Rotsos Tryfon, Symeonidis Chrysanthos, Triantafillopoulou Ioanna, Kanellopoulos Spyridon, Kouris Anastasios
Department of Ophthalmology, General Hospital of Athens, Athens, Greece.
Int Ophthalmol. 2014 Dec;34(6):1271-4. doi: 10.1007/s10792-014-9921-0. Epub 2014 Sep 6.
A significant therapeutic effect in the fellow eye after intravitreal ranibizumab injections was observed in a 39-year-old diabetic male. The patient was followed-up with fluorescein angiography (FA) and Optical Coherence Tomography (OCT). On referral, best-corrected visual acuity (BCVA) was 6/60 in the right eye and Counting Fingers in the left eye. FA revealed foveal leakage in both eyes. OCT revealed diabetic and cystoid macular edema (DME-CME) in both eyes. The patient was treated with two intravitreal ranibizumab injections in the left eye. BCVA was 6/15 and 6/30 one month after the last injection. OCT revealed significant improvement (DME elimination and significant CME improvement) in both eyes, despite the fact that only the left eye was treated. It is conceivable that, in this eye, chronic vascular damage was limited and a minimal quantity of ranibizumab had a positive effect on vascular permeability, resulting in DME resolution.
在一名39岁的糖尿病男性患者中，观察到玻璃体内注射兰尼单抗后对其对侧眼有显著治疗效果。该患者接受了荧光素血管造影（FA）和光学相干断层扫描（OCT）随访。初诊时，右眼最佳矫正视力（BCVA）为6/60，左眼为眼前指数。FA显示双眼黄斑中心凹渗漏。OCT显示双眼存在糖尿病性黄斑水肿和囊样黄斑水肿（DME-CME）。该患者左眼接受了两次玻璃体内兰尼单抗注射。最后一次注射后一个月，BCVA分别为6/15和6/30。OCT显示双眼有显著改善（DME消除，CME显著改善），尽管仅治疗了左眼。可以想象，在这只眼中，慢性血管损伤有限，少量的兰尼单抗对血管通透性产生了积极影响，从而使DME消退。
