Bosco C, Manríquez F, Molina R, Araya J
Rev Med Chil. 1989 Oct;117(10):1102-7.
The chorionic villi tissue of normal term human placentae is made of a highly fibrous extracellular matrix. An increasing amount of fibrous tissue is seen as gestation advances, phenomenon referred as organ aging. Electron microscopy reveals many collagen fibrils close to fibroblasts between the trophoblast and the fetal capillary vessels. A characteristic 67 nm transverse striation produced by the intermixing of tropocollagen and collagen types 1 and 3 is observed. Picrosirius staining under polarized light allowed us to detect abundant type 1 collagen fibers. These were randomly distributed in the stroma but concentrically order around the blood vessels.
足月正常人胎盘的绒毛膜绒毛组织由高度纤维化的细胞外基质组成。随着妊娠进展，可见纤维组织量增加，这种现象称为器官老化。电子显微镜显示，在滋养层和胎儿毛细血管之间靠近成纤维细胞处有许多胶原纤维。观察到原胶原蛋白与1型和3型胶原蛋白混合产生的特征性67纳米横向条纹。偏振光下的天狼星红染色使我们能够检测到丰富的1型胶原纤维。这些纤维随机分布在基质中，但围绕血管呈同心圆排列。
