Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Diabetes Care. 2014 Nov;37(11):3092-7. doi: 10.2337/dc14-0779. Epub 2014 Sep 5.
Left ventricular diastolic dysfunction (LVDD) is considered to be common in patients with type 2 diabetes mellitus (T2DM), but information on its progression over time is lacking. We studied the longitudinal development of left ventricular diastolic function (LVDF) and myocardial blood flow reserve in patients with T2DM who were free from clinically detectable cardiovascular disease.
The LVDF was assessed in 73 patients with T2DM (mean age 67 ± 7 years; males 51%) on two occasions separated by 6.4 ± 0.8 years.
At baseline, LVDD was observed in 23 of the patients (32%). During follow-up, the LVDF normalized in 10 of these patients (43%) and remained unchanged in 13 of them (57%). Of the 50 patients (68%) with normal LVDF at baseline, LVDD developed in 9 (18%). Paired evaluation of myocardial blood volume index was available from 22 patients with LVDD and remained unchanged over time.
The condition of the majority of the investigated patients with LVDD improved or remained stable over a period of 6 years.
左心室舒张功能障碍（LVDD）被认为在 2 型糖尿病（T2DM）患者中很常见，但缺乏关于其随时间进展的信息。我们研究了无临床可检测心血管疾病的 T2DM 患者的左心室舒张功能（LVDF）和心肌血流储备的纵向发展。
在两次随访中，对 73 例 T2DM 患者（平均年龄 67±7 岁；男性占 51%）进行了 LVDF 评估，两次随访间隔 6.4±0.8 年。
在基线时，23 例患者（32%）存在 LVDD。在随访期间，其中 10 例患者（43%）的 LVDF 正常化，13 例患者（57%）保持不变。在基线时 LVDF 正常的 50 例患者（68%）中，9 例（18%）出现 LVDD。有 22 例 LVDD 患者可进行心肌血容量指数的配对评估，其结果随时间保持不变。
在 6 年的时间里，大多数患有 LVDD 的患者的病情改善或保持稳定。
