Raghothama Srivatsa, Rao Akshay
Department of General Medicine, Justice K.S Hegde Medical Academy, Mangalore, Karnataka, India.
Department of General Medicine, Ramaiah Medical College, Bangalore, Karnataka, India.
Caspian J Intern Med. 2021 Fall;12(4):586-592. doi: 10.22088/cjim.12.4.586.
Few studies have used the 2016 American Society of Echocardiography/ European Association of Cardiovascular Imaging (ASE/EACVI) guidelines to detect left ventricular diastolic dysfunction (LVDD) among asymptomatic normotensive type 2 diabetes mellitus (T2DM) patients.
200 asymptomatic non-hypertensive diabetic cases and 281 controls matched for age and body mass index without evidence of arrhythmias, valvular, myocardial, pericardial or coronary artery disease underwent diastology assessment using 2 dimensional and M-mode echocardiography along with tissue Doppler imaging.
The presence of LVDD was seen to be significantly higher among the members of the diabetic group compared to the controls (35 vs. 14; P=0.001). The diabetics with LVDD had a longer duration of diabetes {8.04±7.75 vs. 5.27±5.49 years; P=0.04}, along with higher glycated hemoglobin (HbA1c) {8.40±1.38 vs. 7.80±1.60% ; P=0.05}, fasting blood glucose (FBS) {211.35±78.15 vs. 187.89±107.90 mg/dL; P=0.009, 2 hour post prandial blood glucose} (PPBS) {237.89±107.9 vs. 211.35±78.15 mg/dL; P=0.04}, serum triglyceride (TG) {246.91±171.82 vs. 163.44±99.37 mg/dL; P=0.008} yet had lower serum very low density lipoprotein levels (VLDL) {19.74±15.01 vs. 27.61±17.89 mg/dL; P=0.01}.
This is one of the few studies so far to have demonstrated a higher occurrence of LVDD specifically among asymptomatic normotensive T2DM patients using the 2016 ASE/EACVI guidelines.
很少有研究使用2016年美国超声心动图学会/欧洲心血管影像协会（ASE/EACVI）指南来检测无症状血压正常的2型糖尿病（T2DM）患者中的左心室舒张功能障碍（LVDD）。
200例无症状非高血压糖尿病患者和281例年龄及体重指数匹配且无心律失常、瓣膜、心肌、心包或冠状动脉疾病证据的对照者接受了二维和M型超声心动图以及组织多普勒成像的舒张功能评估。
与对照组相比，糖尿病组患者中LVDD的发生率显著更高（35例对14例；P=0.001）。患有LVDD的糖尿病患者糖尿病病程更长{8.04±7.75对5.27±5.49年；P=0.04}，糖化血红蛋白（HbA1c）更高{8.40±1.38对7.80±1.60%；P=0.05}，空腹血糖（FBS）{211.35±78.15对187.89±107.90mg/dL；P=0.009，餐后2小时血糖}（PPBS）{237.89±107.9对211.35±78.15mg/dL；P=0.04}，血清甘油三酯（TG）{246.91±171.82对163.44±99.37mg/dL；P=0.008}，但血清极低密度脂蛋白水平更低{19.74±15.01对27.61±17.89mg/dL；P=0.01}。
这是迄今为止少数几项使用2016年ASE/EACVI指南证明LVDD在无症状血压正常的T2DM患者中发生率更高的研究之一。
