Lucenti Ausiliatrice, Galimberti Stefania, Barizzone Nadia, Naldi Paola, Comi Giancarlo, Martinelli Boneschi Filippo, D'Alfonso Sandra, Leone Maurizio A
MS Centre, SCDU Neurology, Head and Neck Department, AOU "Maggiore della Carità", Corso Mazzini 18, 28100 Novara, Italy; Department of Health Sciences, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy.
Department of Health Sciences, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy.
J Neurol Sci. 2014 Nov 15;346(1-2):194-6. doi: 10.1016/j.jns.2014.08.021. Epub 2014 Aug 23.
Month of birth has been associated in some studies with the susceptibility to develop Multiple Sclerosis (MS). However, only few studies have evaluated whether birth timing also affects disease progression.
To assess whether season and month of birth are associated with disease progression in a large cohort of Italian patients.
Quantile regression was used to analyze the impact of each month and season of birth with all the others combined on the median Multiple Sclerosis Severity Score of 1866 MS patients.
No significant temporal trend was found after adjustment for multiple comparisons.
Birth timing showed no association with MS progression in Italian patients.
在一些研究中，出生月份与患多发性硬化症（MS）的易感性有关。然而，只有少数研究评估了出生时间是否也会影响疾病进展。
评估出生季节和月份与一大群意大利患者的疾病进展是否相关。
采用分位数回归分析1866例MS患者出生的每个月份和季节与其他所有因素综合对多发性硬化症严重程度评分中位数的影响。
在进行多重比较校正后，未发现明显的时间趋势。
在意大利患者中，出生时间与MS进展无关。
