Pringle Abbie, Harmer Catherine J
Department of Psychiatry, University of Oxford, UK.
Dialogues Clin Neurosci. 2015 Dec;17(4):477-87. doi: 10.31887/DCNS.2015.17.4/apringle.
Human models of emotional processing suggest that the direct effect of successful antidepressant drug treatment may be to modify biases in the processing of emotional information. Negative biases in emotional processing are documented in depression, and single or short-term dosing with conventional antidepressant drugs reverses these biases in depressed patients prior to any subjective change in mood. Antidepressant drug treatments also modulate emotional processing in healthy volunteers, which allows the consideration of the psychological effects of these drugs without the confound of changes in mood. As such, human models of emotional processing may prove to be useful for testing the efficacy of novel treatments and for matching treatments to individual patients or subgroups of patients.
情绪加工的人体模型表明，成功的抗抑郁药物治疗的直接作用可能是改变情绪信息加工中的偏差。抑郁状态下存在情绪加工的负性偏差，在情绪出现任何主观变化之前，给予传统抗抑郁药物单次或短期给药就能逆转抑郁患者的这些偏差。抗抑郁药物治疗还能调节健康志愿者的情绪加工，这使得在不考虑情绪变化干扰的情况下，能够研究这些药物的心理效应。因此，情绪加工的人体模型可能被证明有助于测试新治疗方法的疗效，以及使治疗方法与个体患者或患者亚组相匹配。
