Tajadadi-Ebrahimi Maryam, Bahmani Fereashteh, Shakeri Hossein, Hadaegh Haleh, Hijijafari Mohammad, Abedi Fatemeh, Asemi Zatollah
Science Department, Science Faculty, Islamic Azad University, Tehran Central Branch, Tehran, Iran.
Ann Nutr Metab. 2014;65(1):34-41. doi: 10.1159/000365153. Epub 2014 Sep 4.
This study was conducted to evaluate the effects of daily consumption of synbiotic bread on the metabolic status of patients with type 2 diabetes mellitus.
This randomized, double-blind, controlled clinical trial was performed in 81 diabetic patients. The subjects were randomly assigned to consumption of synbiotic (n = 27), probiotic (n = 27), or control bread (n = 27) for 8 weeks 3 times a day in a 40-gram package. The synbiotic bread contained Lactobacillus sporogenes (1 × 10(8) CFU) and 0.07 g inulin per 1 g. The probiotic bread contained L. sporogenes (1 × 10(8) CFU per 1 g). Fasting blood samples were taken at baseline and after an 8-week intervention for quantification of related factors.
Consumption of the synbiotic bread resulted in a significant reduction in serum insulin levels (-3.2 ± 5.4 vs. -0.3 ± 3.4 and 0.6 ± 4.7 µIU/ml, respectively, p = 0.007), homeostatic model assessment for insulin resistance scores (-1.5 ± 2.7 vs. -0.2 ± 1.6 and 0.4 ± 3.5, respectively, p = 0.03), and homeostatic model assessment-β-cell function (-7.2 ± 16.3 vs. -0.7 ± 10.8 and 0.7 ± 8.2, respectively, p = 0.04) compared to the probiotic and control breads. We did not find any significant effect of synbiotic bread consumption on fasting plasma glucose, the quantitative insulin sensitivity check index, or serum hs-CRP levels compared to other breads.
Consumption of the synbiotic bread among diabetic patients had beneficial effects on insulin metabolism.
本研究旨在评估每日食用合生元面包对2型糖尿病患者代谢状况的影响。
本随机、双盲、对照临床试验在81例糖尿病患者中进行。受试者被随机分配食用合生元面包（n = 27）、益生菌面包（n = 27）或对照面包（n = 27），为期8周，每天3次，每次食用40克包装的面包。合生元面包每1克含有产芽孢乳酸菌（1×10⁸CFU）和0.07克菊粉。益生菌面包每1克含有产芽孢乳酸菌（1×10⁸CFU）。在基线和8周干预后采集空腹血样，以定量相关因素。
与益生菌面包和对照面包相比，食用合生元面包导致血清胰岛素水平显著降低（分别为-3.2±5.4与-0.3±3.4和0.6±4.7μIU/ml，p = 0.007）、胰岛素抵抗稳态模型评估得分显著降低（分别为-1.5±2.7与-0.2±1.6和0.4±3.5，p = 0.03）以及β细胞功能稳态模型评估显著降低（分别为-7.2±16.3与-0.7±10.8和0.7±8.2，p = 0.04）。与其他面包相比，我们未发现食用合生元面包对空腹血糖、定量胰岛素敏感性检查指数或血清hs-CRP水平有任何显著影响。
糖尿病患者食用合生元面包对胰岛素代谢有有益影响。
