益生菌对糖尿病患者氧化应激和炎症标志物的影响：一项荟萃分析研究的元研究

The impact of probiotics on oxidative stress and inflammatory markers in patients with diabetes: a meta-research of meta-analysis studies.

作者信息

Chen Xi, Yan Lijun, Yang Jie, Xu Chenlong, Yang Lv

机构信息

Department of Endocrinology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China.

Department of Geriatric Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, China.

出版信息

Front Nutr. 2025 Mar 7;12:1552358. doi: 10.3389/fnut.2025.1552358. eCollection 2025.

OBJECTIVE

Probiotic supplementation has gained attention for its potential to modulate inflammatory and oxidative stress biomarkers, particularly in metabolic disorders. This meta-analysis evaluates the effects of probiotics on C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione (GSH), and nitric oxide (NO) in patients with diabetes.

METHODS

A Meta-Research was conducted on 15 meta-analyses of unique 33 randomized controlled trials (RCTs) published between 2015 and 2022, involving 26 to 136 participants aged 26 to 66 years. Data were synthesized using standardized mean differences (SMD), with sensitivity analysis using a random-effect model.

RESULTS

Probiotic supplementation significantly reduced CRP (SMD = -0.79, 95% CI: -1.19, -0.38), TNF- (SMD = -1.35, 95% CI: -2.05, -0.66), and MDA levels (WMD: -0.82, 95% CI: -1.16, -0.47). Probiotics increased GSH (SMD = 1.00, 95% CI: 0.41, 1.59), TAC (SMD = 0.48, 95% CI: 0.27, 0.69), and NO (SMD = 0.60, 95% CI: 0.30, 0.91). Result on IL-6 was not significant (SMD = -0.29, 95% CI: -0.66, 0.09). Sensitivity analyses confirmed robustness.

CONCLUSION

Probiotics significantly improved inflammatory and oxidative stress biomarkers in patients with diabetes, with variations influenced by population and dosage. Future studies should explore novel probiotic strains and longer interventions.

目的

补充益生菌因其调节炎症和氧化应激生物标志物的潜力而受到关注，尤其是在代谢紊乱方面。本荟萃分析评估了益生菌对糖尿病患者C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、丙二醛（MDA）、总抗氧化能力（TAC）、谷胱甘肽（GSH）和一氧化氮（NO）的影响。

方法

对2015年至2022年间发表的15项荟萃分析进行了元研究，这些分析涉及33项独特的随机对照试验（RCT），参与者年龄在26至66岁之间，人数从26人到136人不等。使用标准化均数差（SMD）对数据进行综合分析，并采用随机效应模型进行敏感性分析。

结果

补充益生菌可显著降低CRP（SMD = -0.79，95% CI：-1.19，-0.38）、TNF-α（SMD = -1.35，95% CI：-2.05，-0.66）和MDA水平（加权均数差：-0.82，95% CI：-1.16，-0.47）。益生菌可提高GSH（SMD = 1.00，95% CI：0.41，1.59）、TAC（SMD = 0.48，95% CI：0.27，0.69）和NO（SMD = 0.60，95% CI：0.30，0.91）。IL-6的结果不显著（SMD = -0.29，95% CI：-0.66，0.09）。敏感性分析证实了结果的稳健性。