Dikbas Oguz, Tosun Mehmet, Bes Cemal, Tonuk Sukru Burak, Aksehirli Ozge Yilmaz, Soy Mehmet
Department of Endocrinology and Metabolism, School of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
Department of Biochemistry, School of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
Int J Rheum Dis. 2016 Jul;19(7):672-7. doi: 10.1111/1756-185X.12444. Epub 2014 Sep 8.
Psoriatic arthritis (PsA) is an inflammatory form of arthritis typically associated with psoriasis and/or psoriatic nail disease. Adipocytokines were once thought to influence development of (only) insulin resistance and diabetes mellitus. However, it is now clear that adipocytokines play important roles in development of the inflammation associated with either autoimmune or auto-inflammatory disorders. In the present study, we measured changes in the serum levels of adiponectin, resistin and visfatin, and the associations of such changes with the extent of disease activity and insulin resistance in PsA patients.
A total of 67 subjects (28 with PsA and 39 healthy controls) without hypertension or diabetes mellitus were enrolled. Adiponectin, resistin and visfatin levels, and the extent of insulin resistance (assayed using the homeostasis model [HOMA-IR]), were measured in all subjects. Assessment of PsA disease activity was done with the Disease Activity Index for Psoriatic Arthritis (DAPSA).
Psoriatic arthritis patients had considerably higher serum levels of adiponectin, resistin and visfatin than did healthy controls (all P < 0.05). In the logistic regression analysis, the following variables may contribute to complex pathogenesis of PsA: adiponectin (P = 0.001, OR = 3.1, 95% CI = 1.6-6.0), resistin (P = 006, OR = 1.8, 95% CI = 1.2-2.9) and visfatin (P = 0.031, OR = 3.9, 95% CI = 1.1-13.9). In contrast, we have not detected any correlation between DAPSA and adipocytokine serum levels (P > 0.05).
There is no correlation between adipocytokines and disease activity. Although serum adiponectin, resistin and visfatin levels are higher in patients with PsA, pathophysiological significance of the result has to be evaluated with more extensive studies.
银屑病关节炎（PsA）是一种炎症性关节炎，通常与银屑病和/或银屑病甲病相关。脂肪细胞因子曾被认为仅影响胰岛素抵抗和糖尿病的发生发展。然而，现在清楚的是，脂肪细胞因子在与自身免疫性或自身炎症性疾病相关的炎症发生发展中起重要作用。在本研究中，我们检测了银屑病关节炎患者血清脂联素、抵抗素和内脂素水平的变化，以及这些变化与疾病活动程度和胰岛素抵抗的相关性。
共纳入67例无高血压或糖尿病的受试者（28例银屑病关节炎患者和39例健康对照）。检测所有受试者的脂联素、抵抗素和内脂素水平，以及胰岛素抵抗程度（采用稳态模型评估[HOMA-IR]）。采用银屑病关节炎疾病活动指数（DAPSA）评估银屑病关节炎疾病活动度。
银屑病关节炎患者血清脂联素、抵抗素和内脂素水平显著高于健康对照（均P<0.05）。在逻辑回归分析中，以下变量可能与银屑病关节炎的复杂发病机制有关：脂联素（P=0.001，OR=3.1，95%CI=1.6-6.0）、抵抗素（P=0.006，OR=1.8，95%CI=1.2-2.9）和内脂素（P=0.031，OR=3.9，95%CI=1.1-13.9）。相比之下，我们未检测到DAPSA与脂肪细胞因子血清水平之间存在任何相关性（P>0.05）。
脂肪细胞因子与疾病活动度之间无相关性。虽然银屑病关节炎患者血清脂联素、抵抗素和内脂素水平较高，但该结果的病理生理意义有待更广泛的研究来评估。
