Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gómez-Reino J J, Gualillo O
NEIRID (NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases) Laboratory, Santiago University Clinical Hospital, Spain.
Ann Rheum Dis. 2006 Sep;65(9):1198-201. doi: 10.1136/ard.2005.046540. Epub 2006 Jan 13.
Rheumatoid arthritis is a chronic autoimmune inflammatory condition characterised by polyarthritis and severe change in body mass and neuroendocrine environment.
To investigate plasma levels of adipocytokines (leptin, adiponectin, visfatin and resistin) in patients with rheumatoid arthritis and to compare them with levels in healthy controls.
Adiponectin, resistin, visfatin and leptin concentrations were measured in 31 patients with rheumatoid arthritis and 18 healthy controls by using specific enzyme-linked immunosorbent assays.
Patients with rheumatoid arthritis showed considerably higher plasma levels of leptin, adiponectin and visfatin than healthy controls. No marked difference was observed in resistin levels between patients and controls.
A marked increase in plasma levels of leptin, adiponectin and visfatin was noted in patients with rheumatoid arthritis, whereas resistin levels were similar to those observed in healthy controls. Coordinated roles for adiponectin, leptin and visfatin are suggested in the modulation of the inflammatory environment in patients with rheumatoid arthritis, whereas the lack of modulation in resistin levels is predictive of an irrelevant role for this peptide, suggesting that resistin level is probably not one of the main signals associated with the pathogenesis of this disease.
类风湿性关节炎是一种慢性自身免疫性炎症疾病，其特征为多关节炎以及体重和神经内分泌环境的严重变化。
研究类风湿性关节炎患者血浆中脂肪细胞因子（瘦素、脂联素、内脂素和抵抗素）的水平，并与健康对照者的水平进行比较。
采用特异性酶联免疫吸附测定法，对31例类风湿性关节炎患者和18名健康对照者测定脂联素、抵抗素、内脂素和瘦素的浓度。
类风湿性关节炎患者的血浆瘦素、脂联素和内脂素水平显著高于健康对照者。患者与对照者的抵抗素水平未观察到明显差异。
类风湿性关节炎患者血浆中瘦素、脂联素和内脂素水平显著升高，而抵抗素水平与健康对照者相似。脂联素、瘦素和内脂素在调节类风湿性关节炎患者炎症环境中可能发挥协同作用，而抵抗素水平缺乏调节表明该肽可能不发挥主要作用，提示抵抗素水平可能不是与该疾病发病机制相关的主要信号之一。
