Gao Lulu, Lin Peixin, Liu Shuguang, Lei Bin, Chen Qing, Yu Shouyi, Shen Hong
Department of Pathology, School of Basic Medical Sciences, Southern Medical University Tonghe, 510515, Guangzhou, China.
Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University Guangzhou, China.
Int J Clin Exp Pathol. 2014 Jul 15;7(8):5236-41. eCollection 2014.
We report an 8-month-old female infant with the fatal enterovirus 71 infection here. Clinically, she developed respiratory failure and severe pulmonary edema rapidly. Histologically, the lung specimen showed diffuse, severe pulmonary congestion and edema with focal intra-alveolar hemorrhage and typical features of acute encephalitis were easily identified under light microscope. Immunohistochemically, enterovirus 71 antigen was positive in the cerebella and brainstem. We measured the viral loads of different tissues and found that the brainstem and mesenteric lymph nodes showed the highest viral loads among all tissues. We hope that our case report may help to have a better understanding of the enterovirus 71 infection and provide clues to the prevention and treatment of this disease.
我们在此报告一名8个月大的感染致命肠道病毒71型的女婴。临床上，她迅速出现呼吸衰竭和严重肺水肿。组织学上，肺标本显示弥漫性、严重肺充血和水肿，伴有局灶性肺泡内出血，在光学显微镜下很容易识别出急性脑炎的典型特征。免疫组织化学检测显示，肠道病毒71型抗原在小脑和脑干呈阳性。我们测量了不同组织的病毒载量，发现脑干和肠系膜淋巴结的病毒载量在所有组织中最高。我们希望我们的病例报告有助于更好地了解肠道病毒71型感染，并为该病的预防和治疗提供线索。
