Saffie F, Gordillo H, Gordillo E, Ballesteros F
Rev Med Chil. 1989 Nov;117(11):1261-6.
We reviewed the result of treatment of knee osteoarthritis with intraarticular injection of betamethasone derivatives in 100 patients over a 5 year period. Knee involvement was bilateral in 34 of these patients. 1 ml of a mixture of betamethasone dipropionate and betamethasone phosphate was injected intraarticularly in each patient and repeated if needed at 3 week intervals. A total of 496 injections (mean 3.7 per knee, minimum 1 and maximum 18) were performed. Clinical and radiological evaluation before and midway through therapy revealed no side effects. The clinical response in terms of pain, mobility and functional capacity was good. We conclude that the therapy described results in good clinical and functional results over long periods of time in patients with knee osteoarthritis.
我们回顾了在5年期间内对100例膝关节骨关节炎患者进行关节内注射倍他米松衍生物的治疗结果。其中34例患者膝关节双侧受累。向每位患者关节内注射1毫升二丙酸倍他米松和倍他米松磷酸酯的混合物，如有需要，每3周重复注射一次。共进行了496次注射（平均每膝3.7次，最少1次，最多18次）。治疗前及治疗中期的临床和影像学评估均未发现副作用。在疼痛、活动度和功能能力方面的临床反应良好。我们得出结论，所述治疗方法在膝关节骨关节炎患者中能长期产生良好的临床和功能效果。
