Silveri F, Morosini P, Brecciaroli D, Cervini C
Department of Rheumatology, University of Ancona, Italy.
Int J Clin Pharmacol Res. 1994;14(2):79-85.
Recently somatostatin (SST) intra-articular administration has been used in the treatment of some rheumatoid diseases such as rheumatoid arthritis, psoriatic arthritis and osteoarthritis with encouraging results. The aim of this study was to evaluate the efficacy and tolerability of SST intra-articularly injected, involving 20 patients with knee osteoarthritis. Treatment consisted of 4 injections, administered weekly, each of 750 mcg SST. Additionally, in six of them we evaluated the circulating levels of the insulin-like growth factor (IGF)-1 at the base-line time and then every 7 days (immediately before each dose of SST). The results revealed an improvement in pain and in joint function after intra-articular SST, confirmed by statistical analysis. The circulating levels of IGF-1 did not show significant variations following intra-articular administration of SST. The excellent tolerability and the absence of unwanted side-effects with SST allow us to foresee that intra-articular SST could be used in cases of painful knee osteoarthritis, especially in those patients in which other drugs are not appropriate. Moreover, in the absence of modifications of serum levels of IGF-1, SST could be used in athletes.
最近，关节腔内注射生长抑素（SST）已被用于治疗一些类风湿性疾病，如类风湿性关节炎、银屑病关节炎和骨关节炎，取得了令人鼓舞的结果。本研究的目的是评估关节腔内注射SST的疗效和耐受性，纳入了20例膝骨关节炎患者。治疗包括每周注射4次，每次注射750微克SST。此外，我们对其中6例患者在基线时以及之后每7天（每次注射SST前即刻）评估胰岛素样生长因子（IGF）-1的循环水平。结果显示关节腔内注射SST后疼痛和关节功能有所改善，经统计学分析得到证实。关节腔内注射SST后，IGF-1的循环水平未显示出显著变化。SST具有良好的耐受性且无不良副作用，这使我们可以预见，关节腔内注射SST可用于疼痛性膝骨关节炎病例，尤其是在其他药物不合适的患者中。此外，在血清IGF-1水平未发生改变的情况下，SST可用于运动员。
