Lindén C J
Department of Lung Medicine, University Hospital, Lund, Sweden.
In Vivo. 1989 Jul-Aug;3(4):259-62.
The toxicity of eight anticancer drugs given intraperitoneally to athymic rats was investigated to define the maximum tolerable doses (MTD). Drugs were given once weekly. Toxicity was assessed as percentage loss of body weight (LBW%) or percentage toxic death rate (TDR%) during the first week after drug administration. LBW% and TDR% were significantly correlated, r = 0.58 p less than 0.00001. From the regression equation for the relationship between LBW% and TDR%, 10 percent TDR (LD10), usually regarded as equivalent to MTD in animals, was found to correspond to 14 percent LBW. From the individual regression equations for LBW% and dose for each of six drugs, MTDs were calculated to be as follows; doxorubicin 7 mg/kg, cyclophosphamide 100 mg/kg, mitomycin C 1.8 mg/kg, cisplatin 8 mg/kg, vindesine 0.8 mg/kg and vincristine 0.9 mg/kg. LD10 was found to be 40 mg/kg for both carmustine (BCNU) and etoposide.
研究了八种抗癌药物腹腔注射给无胸腺大鼠的毒性，以确定最大耐受剂量（MTD）。药物每周给药一次。毒性评估为给药后第一周体重减轻百分比（LBW%）或毒性死亡率百分比（TDR%）。LBW%与TDR%显著相关，r = 0.58，p小于0.00001。根据LBW%与TDR%关系的回归方程，通常在动物中被视为等同于MTD的10%TDR（LD10）被发现对应于14%LBW。根据六种药物各自的LBW%与剂量的个体回归方程，计算出的MTD如下：阿霉素7 mg/kg、环磷酰胺100 mg/kg、丝裂霉素C 1.8 mg/kg、顺铂8 mg/kg、长春地辛0.8 mg/kg和长春新碱0.9 mg/kg。卡莫司汀（BCNU）和依托泊苷的LD10均为40 mg/kg。
