Mizushima Y, Li H, Sassa K, Fujishita T, Oosaki R, Kobayashi M
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Anticancer Res. 1997 Nov-Dec;17(6D):4611-4.
As part of the study of the appropriate usage of anticancer drugs, and the effects of the administration method (single dose, or divided doses) on the death rate from toxicity, five anticancer drugs (nimustine hydrochloride = ACNU, cyclophosphamide = CY, carboplatine = CBDCA, mitomycin C = MMC, vindesine = VDS) were studied in F-344 rats. A reduced death rate from toxicity was achieved by divided-dose administration of ACNU and CBDCA (group 1), but it was higher for CY and VDS (group 2), and there was no significant difference with MMC (group 3). In conclusion, the drugs were divided into three groups according to the administration method-related toxicity patterns. Improved knowledge of the properties of anticancer drugs is important for the success of chemotherapy.
作为抗癌药物合理使用以及给药方式（单剂量或分剂量）对毒性死亡率影响研究的一部分，在F-344大鼠中对五种抗癌药物（盐酸尼莫司汀=ACNU、环磷酰胺=CY、卡铂=CBDCA、丝裂霉素C=MMC、长春地辛=VDS）进行了研究。ACNU和CBDCA分剂量给药可降低毒性死亡率（第1组），但CY和VDS的毒性死亡率更高（第2组），MMC则无显著差异（第3组）。总之，根据与给药方式相关的毒性模式，这些药物被分为三组。对抗癌药物特性的深入了解对化疗的成功至关重要。
