泰国分离出的耐多药结核菌株的二线药物敏感性：最新情况
Second-line drug susceptibilities of multidrug-resistant tuberculosis strains isolated in Thailand: an update.
作者信息
Chaiprasert A, Srimuang S, Tingtoy N, Makhao N, Sirirudeeporn P, Tomnongdee N, Theankeaw O, Charoensook S, Leechawengwongs M, Prammananan T
机构信息
<label>*</label>Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
<label><sup>†</sup></label>Drug-Resistant Tuberculosis Research Fund, Siriraj Foundation, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
出版信息
Int J Tuberc Lung Dis. 2014 Aug;18(8):961-3. doi: 10.5588/ijtld.13.0197.
The increasing incidence of multidrug-resistant tuberculosis (MDR-TB) and the emergence of extensively drug-resistant tuberculosis (XDR-TB) globally hamper the successful treatment and effective control of TB. Information on second-line drug susceptibility, which is of utmost importance for patient care, is still limited. This study demonstrates the susceptibilities of 1447 strains of MDR-TB, including 58 XDR-TB strains, isolated from Siriraj Hospital, Bangkok, Thailand, to aminoglycosides, fluoroquinolones, ethionamide (ETH), para-aminosalicylic acid (PAS) and linezolid. Results revealed that 93-94% of the MDR-TB strains were susceptible to aminoglycosides, 85-98% to fluoroquinolones, 78% to ETH, 85% to PAS and 99% to linezolid.
全球耐多药结核病（MDR-TB）发病率不断上升以及广泛耐药结核病（XDR-TB）的出现，阻碍了结核病的成功治疗和有效控制。对于患者护理至关重要的二线药物敏感性信息仍然有限。本研究展示了从泰国曼谷诗里拉吉医院分离出的1447株耐多药结核菌株（包括58株广泛耐药结核菌株）对氨基糖苷类、氟喹诺酮类、乙硫异烟胺（ETH）、对氨基水杨酸（PAS）和利奈唑胺的敏感性。结果显示，93%-94%的耐多药结核菌株对氨基糖苷类敏感，85%-98%对氟喹诺酮类敏感，78%对乙硫异烟胺敏感，85%对PAS敏感，99%对利奈唑胺敏感。
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