Maclean Jillian, Breau Rodney H, Scheida Nicola, Malone Shawn
The Ottawa Hospital, Ottawa, Canada.
BMJ Case Rep. 2014 Sep 8;2014:bcr2014206015. doi: 10.1136/bcr-2014-206015.
Renal cell carcinoma (RCC) is generally poorly responsive to conventional radiation doses, and patients with inoperable local recurrence have limited therapeutic options. Stereotactic body radiotherapy (SBRT) is an increasingly available technology that allows delivery of a radiation schedule providing doses far more biologically effective against cancer cells than conventional radiotherapy. We present a case where durable disease control was achieved using SBRT in a patient with inoperable locally recurrent RCC who presented 18 years from original nephrectomy. The patient remains asymptomatic with no evidence of active disease 30 months following SBRT. This case highlights the need to reconsider the role of therapies with continuing advances in technology.
肾细胞癌（RCC）通常对传统放射剂量反应不佳，无法手术的局部复发患者的治疗选择有限。立体定向体部放射治疗（SBRT）是一种越来越普及的技术，它能够提供一种放射治疗方案，该方案所提供的剂量对癌细胞的生物有效性远高于传统放疗。我们报告了一例使用SBRT治疗无法手术的局部复发性RCC患者并实现持久疾病控制的病例，该患者自初次肾切除术后18年出现复发。SBRT治疗30个月后，患者仍无症状，也没有疾病活动的迹象。该病例凸显了随着技术不断进步，有必要重新审视各种治疗方法的作用。
