Yang Lina, Bian Gaorui, Zhu Weiyun
Wei Sheng Wu Xue Bao. 2014 May 4;54(5):480-6.
The large numbers of microorganisms that inhabit mammalian gastro-intestine have a highly coevolved relationship with the host's health in nutrition, immunity and other aspects. There is a complex relationship between microbiota and immune system. Although they can inhibit the pathogens invade epithelial tissue, many of these microbes have functions that are critical for stimulating host intestinal immune cells such as Tregs cells, Th17 cells differentiation. However, the disorder of the intestinal flora can cause bacterial translocation, intestinal barrier dysfunction. The mammalian immune system plays an essential role in maintaining homeostasis with resident microbial communities, though secreting a variety of immune effector cytokines such as MUC, sIgA, ITF, RegIIIgamma, and alpha-defensins. Here, we review the composition of intestinal flora on simple stomach animal and the interactions between resident microbes and the immune function.
寄居于哺乳动物胃肠道的大量微生物与宿主在营养、免疫等方面的健康状况有着高度协同进化的关系。微生物群与免疫系统之间存在复杂的关系。尽管它们能够抑制病原体侵袭上皮组织，但其中许多微生物对于刺激宿主肠道免疫细胞（如调节性T细胞、辅助性T细胞17亚群细胞分化）的功能至关重要。然而，肠道菌群紊乱会导致细菌移位、肠道屏障功能障碍。哺乳动物免疫系统通过分泌多种免疫效应细胞因子（如黏蛋白、分泌型免疫球蛋白A、肠三叶因子、再生胰岛衍生蛋白IIIγ和α-防御素），在维持与常驻微生物群落的内环境稳定方面发挥着重要作用。在此，我们综述了单胃动物肠道菌群的组成以及常驻微生物与免疫功能之间的相互作用。
