糖化白蛋白与急性起病的1型糖尿病患者的体重指数无显著相关性。

Glycated albumin is not significantly correlated with body mass index in patients with acute-onset type 1 diabetes.

作者信息

Hirata Takumi, Koga Masafumi, Kasayama Soji, Morimoto Jiro, Maruyama Taro

机构信息

Foundation for Biomedical Research and Innovation, Kobe, Japan.

Department of Internal Medicine, Kawanishi City Hospital, Hyogo, Japan.

出版信息

Clin Chim Acta. 2015 Jan 1;438:248-51. doi: 10.1016/j.cca.2014.08.038. Epub 2014 Sep 6.

DOI:10.1016/j.cca.2014.08.038

PMID:25199854

Abstract

BACKGROUND

No previous reports have clarified the relationship between glycated albumin (GA) and BMI in patients with acute-onset type 1 diabetes.

METHODS

We conducted a cross-sectional study evaluating the correlation between GA and BMI in 209 patients with acute-onset type 1 diabetes and in 159 patients with type 2 diabetes who were designated as the control group. The correlation between fasting serum C-peptide immunoreactivity (CPR) and GA or BMI was also evaluated to clarify the impact of insulin secretion capacity on the relationship between GA and BMI.

RESULTS

GA was significantly inversely correlated with BMI in patients with type 2 diabetes (r=-0.317, p<0.001) but not in patients with type 1 diabetes (r=0.031, p=NS). In patients with type 2 diabetes, GA was significantly inversely correlated with fasting CPR, and BMI was significantly correlated with fasting CPR. In patients with type 1 diabetes, GA was significantly inversely correlated with fasting CPR (r=-0.291, p<0.001), but BMI was not correlated with fasting CPR (r=-0.010, p=NS).

CONCLUSIONS

Unlike in patients with type 2 diabetes, GA was not significantly correlated with BMI in patients with acute-onset type 1 diabetes.

摘要

背景

既往尚无报道阐明急性起病的1型糖尿病患者糖化白蛋白（GA）与体重指数（BMI）之间的关系。

方法

我们进行了一项横断面研究，评估了209例急性起病的1型糖尿病患者和159例2型糖尿病患者（作为对照组）中GA与BMI之间的相关性。还评估了空腹血清C肽免疫反应性（CPR）与GA或BMI之间的相关性，以阐明胰岛素分泌能力对GA与BMI之间关系的影响。

结果

GA在2型糖尿病患者中与BMI显著负相关（r=-0.317，p<0.001），但在1型糖尿病患者中无相关性（r=0.031，p=无统计学意义）。在2型糖尿病患者中，GA与空腹CPR显著负相关，BMI与空腹CPR显著相关。在1型糖尿病患者中，GA与空腹CPR显著负相关（r=-0.291，p<0.001），但BMI与空腹CPR无相关性（r=-0.010，p=无统计学意义）。