Mo Yifei, Ma Xiaojing, Li Hong, Ran Xingwu, Yang Wenying, Li Qiang, Peng Yongde, Li Yanbing, Gao Xin, Luan Xiaojun, Wang Weiqing, Xie Yun, Zhou Jian, Jia Weiping
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.
Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Diabetes Res Clin Pract. 2016 May;115:17-23. doi: 10.1016/j.diabres.2016.03.003. Epub 2016 Mar 7.
To determine the relationship between glycated albumin (GA) and glycated hemoglobin (HbA1c) and to explore the association of glycated albumin/glycated hemoglobin (GA/HbA1c) ratio with glucose indices in Chinese subjects with varying glucose tolerance status.
This hospital-based, cross-sectional study involved 953 participants without known diabetes from 11 centers in China. Oral glucose tolerance test (OGTT) was used to identify three groups of subjects: normal glucose regulation (n=194), impaired glucose regulation (n=303) and newly diagnosed type 2 diabetes group (n=456). The GA, HbA1c and GA/HbA1c ratio were tested.
GA was positively correlated with HbA1c (r=0.832, P<0.001). After correcting for age, sex and BMI, the correlations remained significant (r=0.824, P<0.001). Linear regression analysis estimated that a 1% increase of HbA1c was associated with a 2.84% increase of GA (GA=2.843×HbA1c-0.203; R(2)=0.692, P<0.001). GA would be 18.3 (16.7-19.9)% and 19.7 (18.0-21.4)% with HbA1c of 6.5% (48mmol/mol) and 7.0% (53mmol/mol). The mean GA/HbA1c ratio was 2.81±0.38, and it significantly increased with the presence of glucose intolerance (all, P<0.05). In the total study population, GA/HbA1c was correlated with BMI, glucose levels and 30-min insulin during OGTT, the homeostatic model assessment of β-cell function (HOMA-β), and ΔI30/ΔG30 (all, P<0.05). Increased glucose at 30min (standardized β=0.221, P<0.001), and decreased BMI (standardized β=-0.114, P=0.008) were associated with elevated GA/HbA1c ratio by multiple linear regression (adjusted R(2)=0.045).
The relationship between GA and HbA1c was strong. The GA/HbA1c ratio was related to acute postprandial glucose fluctuation and BMI level.
确定糖化白蛋白（GA）与糖化血红蛋白（HbA1c）之间的关系，并探讨糖化白蛋白/糖化血红蛋白（GA/HbA1c）比值与不同糖耐量状态中国受试者血糖指标的关联。
这项基于医院的横断面研究纳入了来自中国11个中心的953名无糖尿病史的参与者。采用口服葡萄糖耐量试验（OGTT）来确定三组受试者：血糖正常调节（n = 194）、糖调节受损（n = 303）和新诊断的2型糖尿病组（n = 456）。检测GA、HbA1c和GA/HbA1c比值。
GA与HbA1c呈正相关（r = 0.832，P < 0.001）。校正年龄、性别和BMI后，相关性仍然显著（r = 0.824，P < 0.001）。线性回归分析估计，HbA1c每增加1%，GA增加2.84%（GA = 2.843×HbA1c - 0.203；R(2)=0.692，P < 0.001）。当HbA1c为6.5%（48mmol/mol）和7.0%（53mmol/mol）时，GA分别为18.3（16.7 - 19.9）%和19.7（18.0 - 21.4）%。GA/HbA1c比值的平均值为2.81±0.38，随着糖耐量异常的出现显著升高（均P < 0.05）。在整个研究人群中，GA/HbA1c与BMI、血糖水平、OGTT期间30分钟胰岛素水平、β细胞功能的稳态模型评估（HOMA-β）以及ΔI30/ΔG30均相关（均P < 0.05）。多元线性回归分析显示，30分钟时血糖升高（标准化β = 0.221，P < 0.001）和BMI降低（标准化β = -0.114，P = 0.008）与GA/HbA1c比值升高相关（校正R(2)=0.045）。
GA与HbA1c之间关系密切。GA/HbA1c比值与餐后急性血糖波动和BMI水平相关。
