Ray S
Med J Malaysia. 1989 Dec;44(4):351-3.
A 60 year old woman with chronic duodenal ulcer not responding to Cimetidine, was changed to Ranitidine. She had symptomatic improvement, but had bilateral breast engorgement and tenderness for which treatment was discontinued. A therapeutic trial on a second occasion had the same side effect which came on more rapidly and quickly. This complication in such severe form and recurrence on rechallenge requiring withdrawal of drug was observed for the first time with any H2 receptor antagonist.
一名60岁患有慢性十二指肠溃疡的女性，使用西咪替丁治疗无效，改用雷尼替丁。她的症状有所改善，但出现了双侧乳房胀痛和压痛，因此停药。第二次进行治疗试验时出现了同样的副作用，且发作更快、更迅速。这种严重形式的并发症以及再次用药时复发且需要停药的情况，在任何H2受体拮抗剂中都是首次观察到。
