Hüttemann W
Fortschr Med. 1983 Jan 27;101(4):139-41.
60 out-patients with acute duodenal ulcers were treated in an open randomized trial with 2 x 150 mg ranitidine or 2 x 400 mg cimetidine, respectively. At endoscopy after 12 and 24 days there was evidence of complete healing in 63% and 93% in the ranitidine- and 57% and 83% in the cimetidine-treated group. Although the symptoms in both groups improved during treatment with H2-blockers, there was a more rapid relief in pain in the ranitidine-group (p less than 0.01). The more favorable results with ranitidine, 150 mg twice daily, warrant further clinical evaluation.
60例急性十二指肠溃疡门诊患者参与了一项开放随机试验，分别接受2×150毫克雷尼替丁或2×400毫克西咪替丁治疗。在12天和24天后的内镜检查中，雷尼替丁治疗组的溃疡完全愈合率分别为63%和93%，西咪替丁治疗组分别为57%和83%。尽管两组患者在使用H2阻滞剂治疗期间症状均有所改善，但雷尼替丁组的疼痛缓解更为迅速（p<0.01）。每日两次服用150毫克雷尼替丁的更佳疗效值得进一步临床评估。
