墨西哥人群中心外膜脂肪组织、冠状动脉疾病与脂联素之间的关系。
Relationship between epicardial adipose tissue, coronary artery disease and adiponectin in a Mexican population.
作者信息
Yañez-Rivera Teresa G, Baños-Gonzalez Manuel A, Ble-Castillo Jorge L, Torres-Hernandez Manuel E, Torres-Lopez Jorge E, Borrayo-Sanchez Gabriela
机构信息
Centro de Investigación y Posgrado, DACS, Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa, Tabasco, Mexico.
出版信息
Cardiovasc Ultrasound. 2014 Sep 8;12:35. doi: 10.1186/1476-7120-12-35.
BACKGROUND
The amount of epicardial adipose tissue (EAT) around the heart has been identified as an independent predictor of coronary artery disease (CAD), potentially through local release of inflammatory cytokines. Ethnic differences have been observed, but no studies have investigated this relationship in the Mexican population. The objective of the present study was to evaluate whether a relationship exist between EAT thickness assessed via echocardiography with CAD and adiponectin levels in a Mexican population.
METHODS
We studied 153 consecutive patients who underwent coronary angiography and transthoracic echocardiography (TTE). EAT thickness on the free wall of the right ventricle was measured at the end of systole from parasternal long and short axis views of three consecutive cardiac cycles. Coronary angiograms were analyzed for the presence, extent and severity of CAD. Serum adiponectin, lipids, glucose, C-reactive protein and fibrinogen were determined.
RESULTS
EAT thickness was greater in patients with CAD than in those without CAD from both parasternal long (5.39 ± 1.75 mm vs 4.00 ± 1.67 mm p<0.0001) and short-axis views (5.23 ± 1.67 vs 4.12 ± 1.77, p=0.001). EAT thickness measured from parasternal long and short-axis showed a statistically significant positive correlation with age (r=0.354, p<0.001; r=0.286, p<0.001 respectively), and waist circumference (r=0.189, p=0.019; r=0.217, p=0.007 respectively). A significant negative correlation between EAT thickness from the parasternal long axis with cholesterol-HDL was observed (r=-0.163, p=0.045). No significant correlation was found between epicardial fat thickness and serum adiponectin or with the severity of CAD.
CONCLUSIONS
EAT thickness was greater in patients with CAD. However, no correlation was observed with the severity of the disease or with serum adiponectin levels. EAT thickness measured by echocardiography might provide additional information for risk assessment and prediction of CAD.
背景
心脏周围的心外膜脂肪组织（EAT）量已被确定为冠状动脉疾病（CAD）的独立预测指标，可能是通过局部释放炎性细胞因子实现的。已观察到种族差异，但尚无研究在墨西哥人群中调查这种关系。本研究的目的是评估在墨西哥人群中，通过超声心动图评估的EAT厚度与CAD及脂联素水平之间是否存在关系。
方法
我们研究了153例连续接受冠状动脉造影和经胸超声心动图（TTE）检查的患者。在三个连续心动周期的胸骨旁长轴和短轴视图的收缩期末，测量右心室游离壁的EAT厚度。分析冠状动脉造影以确定CAD的存在、范围和严重程度。测定血清脂联素、脂质、葡萄糖、C反应蛋白和纤维蛋白原。
结果
无论是从胸骨旁长轴（5.39±1.75mm对4.00±1.67mm，p<0.0001）还是短轴视图（5.23±1.67对4.12±1.77，p=0.001）来看，CAD患者的EAT厚度均大于无CAD患者。从胸骨旁长轴和短轴测量的EAT厚度与年龄（分别为r=0.354，p<0.001；r=0.286，p<0.001）以及腰围（分别为r=0.189，p=0.019；r=0.217，p=0.007）呈统计学显著正相关。观察到胸骨旁长轴的EAT厚度与胆固醇-HDL之间存在显著负相关（r=-0.163，p=0.045）。未发现心外膜脂肪厚度与血清脂联素或CAD严重程度之间存在显著相关性。
结论
CAD患者的EAT厚度更大。然而，未观察到其与疾病严重程度或血清脂联素水平之间存在相关性。通过超声心动图测量的EAT厚度可能为CAD的风险评估和预测提供额外信息。
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