Department of Chemical and Materials Engineering, Chang Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan; Biosensor Group, Biomedical Engineering Research Center, Chang Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan.
Department of Chemical and Materials Engineering, Chang Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan.
Biosens Bioelectron. 2015 May 15;67:327-33. doi: 10.1016/j.bios.2014.08.046. Epub 2014 Aug 23.
We demonstrate the microwave-assisted synthesis of short graphene oxide nanoribbons (GONRs) through unzipping cut multiwalled carbon nanotubes (MWCNTs). Transmission electron microscopy and dynamic light scattering spectroscopy were used to examine the length, size, and morphology, i. e. unzipping level, of our various products. The nanotube core and nanoribbon shell can be observed from short GONRs via a modified unzipping recipe. Then the short GONRs were adopted to modify the glassy carbon electrode for the electrochemical detection of ascorbic acid (AA), uric acid (UA), and dopamine (DA). Compared to other nanomaterials, cyclic voltammograms of short GONRs show higher anodic oxidation currents for AA, UA, and DA. The detection limits of three analytes are 26, 98, and 24 nM, respectively, in amperometric current-time measurements. Especially, the sensitivity for DA is improved to be 40.86 μA μM(-1) cm(-2). The improved detection signals are due to the increased active sites of the open ends of short GONRs. Moreover, the width side of short GONRs could be more active than their length side. All above-mentioned results reveal that the short GONRs can provide a novel platform for electrochemically biomarker detection of Parkinson's disease.
我们通过解卷曲作用展示了微波辅助合成短石墨烯纳米带（GONRs）的过程，这种解卷曲作用来自于切割后的多壁碳纳米管（MWCNTs）。透射电子显微镜和动态光散射光谱被用于检测我们的各种产物的长度、尺寸和形态，也就是解卷曲水平。从经过改良的解卷曲配方中，我们可以观察到短 GONRs 中的纳米管核心和纳米带外壳。然后，我们将短 GONRs 用于修饰玻碳电极，以电化学方式检测抗坏血酸（AA）、尿酸（UA）和多巴胺（DA）。与其他纳米材料相比，短 GONRs 的循环伏安图显示出 AA、UA 和 DA 的阳极氧化电流更高。在安培电流时间测量中，三种分析物的检测限分别为 26、98 和 24 nM。特别是，DA 的灵敏度提高到 40.86 μA μM(-1) cm(-2)。检测信号的改善是由于短 GONRs 的开口端增加了活性位点。此外，短 GONRs 的宽度侧可能比长度侧更活跃。所有上述结果表明，短 GONRs 可以为帕金森病的生物标志物电化学检测提供一个新的平台。
