中国东北地区人群中ADAM33基因多态性与瘢痕疙瘩的关联
Association of ADAM33 gene polymorphisms with keloid scars in a northeastern Chinese population.
作者信息
Han Jianyu, Han Jianfeng, Yu Dongmei, Xiao Jinling, Shang Yong, Hao Lijun
机构信息
Plastic and Cosmetic Center, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
出版信息
Cell Physiol Biochem. 2014;34(3):981-7. doi: 10.1159/000366314. Epub 2014 Aug 27.
OBJECTIVE
To study the association between ADAM33 and keloid scars in the northeastern Chinese population.
METHODS
A total of 283 keloid scar patients and a control group of 290 healthy volunteers were recruited for this study. Six polymorphic loci (V4, T+1, T2, T1, S2 and Q-1 ) of ADAM33 were selected for genotyping. Genotypes were determined by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
RESULTS
We observed the frequency of the rs612709 A allele exhibited a significantly decreased frequency in cases than in controls(22 vs.39.6%, P<0.0001) We also found that the frequencies of H2 (GGAAGA) haplotypes was significantly higher in the case group than in the control group (P= 0.041). In contrast, the haplotype H8 (GGGAGG) was more common in the control group than in the case group (P=0.022).
CONCLUSIONS
Our data suggest that the ADAM33 polymorphisms may be associated with keloid scars in the northeastern Chinese population.
目的
研究中国东北人群中ADAM33与瘢痕疙瘩之间的关联。
方法
本研究共招募了283例瘢痕疙瘩患者和290名健康志愿者作为对照组。选择ADAM33的六个多态性位点（V4、T+1、T2、T1、S2和Q-1）进行基因分型。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法确定基因型。
结果
我们观察到，病例组中rs612709 A等位基因的频率显著低于对照组（22%对39.6%，P<0.0001）。我们还发现，病例组中H2（GGAAGA）单倍型的频率显著高于对照组（P=0.041）。相反，H8（GGGAGG）单倍型在对照组中比病例组更常见（P=0.022）。
结论
我们的数据表明，ADAM33基因多态性可能与中国东北人群的瘢痕疙瘩有关。
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