REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
Water Res. 2014 Dec 1;66:160-168. doi: 10.1016/j.watres.2014.08.024. Epub 2014 Aug 27.
Industrial and urban activities yield large amounts of contaminated groundwater, which present a major health issue worldwide. Infectious diseases are the most common health risk associated with drinking-water and wastewater remediation is a major concern of our modern society. The field of wastewater treatment is being revolutionized by new nano-scale water disinfection devices which outperform most currently available technologies. In particular, iron oxide magnetic nanoparticles (MNPs) have been widely used in environmental applications due to their unique physical-chemical properties. In this work, poly(ethylene) glycol (PEG)-coated MNPs have been functionalized with (RW)3, an antimicrobial peptide, to yield a novel magnetic-responsive support with antimicrobial activity against Escherichia coli K-12 DSM498 and Bacillus subtilis 168. The magnetic-responsive antimicrobial device showed to be able to successfully disinfect the surrounding solution. Using a rapid high-throughput screening platform, the minimal inhibitory concentration (MIC) was determined to be 500 μM for both strains with a visible bactericidal effect.
工业和城市活动产生大量受污染的地下水，这是一个全球性的主要健康问题。传染病是与饮用水相关的最常见健康风险，废水处理是我们现代社会的主要关注点。新型纳米级水消毒设备正在彻底改变废水处理领域，其性能优于大多数现有技术。特别是，由于具有独特的物理化学性质，氧化铁磁性纳米颗粒（MNPs）已广泛应用于环境应用中。在这项工作中，聚乙二醇（PEG）包覆的 MNPs 已用（RW）3 进行功能化，（RW）3 是一种抗菌肽，可得到一种具有针对大肠杆菌 K-12 DSM498 和枯草芽孢杆菌 168 的抗菌活性的新型磁响应载体。该磁响应抗菌装置能够成功对周围溶液进行消毒。使用快速高通量筛选平台，确定两种菌株的最小抑菌浓度（MIC）均为 500 μM，具有明显的杀菌作用。
