Frey H H
Department of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, West Germany.
Probl Vet Med. 1989 Oct-Dec;1(4):558-77.
The pharmacology of anticonvulsant drugs is reviewed with emphasis placed on the treatment of canine and feline epilepsy. Due to pharmacokinetic reasons, only phenobarbital, primidone, and, with certain limitations, the benzodiazepines can be used in dogs. Bromides may be given additionally in cases that cannot be controlled with phenobarbital or promidone therapy. In cats, diazepam has been shown to be very useful because no tolerance develops to the antiepileptic effect in this species.
本文综述了抗惊厥药物的药理学，重点在于犬猫癫痫的治疗。由于药代动力学原因，犬仅可使用苯巴比妥、扑米酮以及有一定限制的苯二氮䓬类药物。在苯巴比妥或扑米酮治疗无法控制的情况下，可额外给予溴化物。在猫中，地西泮已被证明非常有用，因为该物种对抗癫痫作用不会产生耐受性。
