生酮饮食对癫痫发作的抗惊厥作用及其潜在机制。
The Anticonvulsant Effects of Ketogenic Diet on Epileptic Seizures and Potential Mechanisms.
机构信息
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
出版信息
Curr Neuropharmacol. 2018;16(1):66-70. doi: 10.2174/1570159X15666170517153509.
BACKGROUND
Epilepsy is a syndrome of brain dysfunction induced by the aberrant excitability of certain neurons. Despite advances in surgical technique and anti-epileptic drug in recent years, recurrent epileptic seizures remain intractable and lead to a serious morbidity in the world. The ketogenic diet refers to a high-fat, low-carbohydrate and adequate-protein diet. Currently, its beneficial effects on epileptic seizure reduction have been well established. However, the detailed mechanisms underlying the anti-epileptic effects of ketogenic diet are still poorly understood. In this article, the possible roles of ketogenic diet on epilepsy were discussed.
METHODS
Data was obtained from the websites including Web of Science, Medline, Pubmed, Scopus, based on these keywords: "Ketogenic diet" and "epilepsy".
RESULTS
As shown in both clinical and basic studies, the therapeutic effects of ketogenic diet might involve neuronal metabolism, neurotransmitter function, neuronal membrane potential and neuron protection against ROS.
CONCLUSION
In this review, we systematically reviewed the effects and possible mechanisms of ketogenic diet on epilepsy, which may optimize the therapeutic strategies against epilepsy.
背景
癫痫是由特定神经元异常兴奋引起的脑功能障碍综合征。尽管近年来手术技术和抗癫痫药物有所进步，但复发性癫痫发作仍难以治疗，并在世界范围内导致严重的发病率。生酮饮食是指一种高脂肪、低碳水化合物和适量蛋白质的饮食。目前，其对减少癫痫发作的有益效果已得到充分证实。然而，生酮饮食抗癫痫作用的详细机制仍知之甚少。本文讨论了生酮饮食在癫痫中的可能作用。
方法
从 Web of Science、Medline、Pubmed、Scopus 等网站获取数据，基于以下关键词：“生酮饮食”和“癫痫”。
结果
临床和基础研究均表明，生酮饮食的治疗效果可能涉及神经元代谢、神经递质功能、神经元膜电位和神经元对 ROS 的保护。
结论
在本综述中，我们系统地综述了生酮饮食对癫痫的作用及其可能的机制，这可能优化了针对癫痫的治疗策略。
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