Archer David F
Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 601 Colley Avenue, Norfolk, VA 23507, USA.
J Steroid Biochem Mol Biol. 2015 Jan;145:139-43. doi: 10.1016/j.jsbmb.2014.09.003. Epub 2014 Sep 6.
The effects of intravaginal administration of dehydroepiandrosterone (DHEA) for the management of symptomatic vulvovaginal atrophy are reviewed. A literature search related to vulvovaginal atrophy, vaginal atrophy, atrophic vaginitis, estrogen, dehydroepiandrosterone, vulvar itching, burning, dryness, dyspareunia, and libido was performed. Relevant articles addressing the incidence, management, and outcome of DHEA therapy were identified and used for this Expert Opinion. DHEA compared to a placebo is an effective treatment improving symptoms of vaginal atrophy: dyspareunia, burning, itching, and dryness. Objective parameters of vaginal atrophy, specifically pH, vaginal maturation index (VMI), and investigator-evaluated changes in the vagina: moisture, epithelia integrity and color were improved compared to baseline and placebo. There were significant improvements in libido and dyspareunia with the intravaginal use of DHEA that contribute to improved quality of life for postmenopausal women. Dehydroepiandrosterone administered intravaginally on a daily basis is an effective treatment for symptoms, and signs of vulvovaginal atrophy along with libido in postmenopausal women. This article is part of a Special Issue entitled 'Essential role of DHEA'.
本文综述了经阴道给予脱氢表雄酮（DHEA）治疗有症状的外阴阴道萎缩的效果。我们进行了一项文献检索，内容涉及外阴阴道萎缩、阴道萎缩、萎缩性阴道炎、雌激素、脱氢表雄酮、外阴瘙痒、灼痛、干燥、性交困难和性欲。确定了有关DHEA治疗的发病率、管理和结果的相关文章，并用于本专家意见。与安慰剂相比，DHEA是一种有效的治疗方法，可改善阴道萎缩的症状：性交困难、灼痛、瘙痒和干燥。与基线和安慰剂相比，阴道萎缩的客观参数，特别是pH值、阴道成熟指数（VMI）以及研究者评估的阴道变化：湿度、上皮完整性和颜色均得到改善。经阴道使用DHEA可显著改善性欲和性交困难，有助于提高绝经后妇女的生活质量。每日经阴道给予脱氢表雄酮是治疗绝经后妇女外阴阴道萎缩症状、体征以及性欲的有效方法。本文是名为“DHEA的重要作用”的特刊的一部分。
