Pięta Wojciech, Smolarczyk Roman
Department of Gynecological Endocrinology, Medical University of Warsaw, Poland.
Prz Menopauzalny. 2020 Dec;19(4):195-199. doi: 10.5114/pm.2020.101943. Epub 2021 Jan 7.
During the menopause, a fall in estrogen levels often leads to many unfavorable symptoms, including changes in the vascular and urogenital systems, in mood, and sleep. The symptoms of vulvovaginal atrophy are especially troublesome for menopausal women. These symptoms not only disturb the sexual sphere, but also functioning at work and in the family. Based on the literature, a review of contemporary methods of management in the case of symptoms of vulvar atrophy in menopausal women has been performed. The current methods of treating vulvovaginal atrophy in menopausal women are described. The pharmacology of the available dehydroepiandrosterone (DHEA) preparations, both oral and vaginal, was briefly analyzed. Own experiences of using DHEA are presented. Vaginal DHEA has been found to be an effective and safe treatment in menopausal women with symptoms of vaginal atrophy.
在更年期期间，雌激素水平下降常常导致许多不良症状，包括血管和泌尿生殖系统的变化、情绪和睡眠方面的改变。外阴阴道萎缩症状对更年期女性来说尤其困扰。这些症状不仅扰乱了性方面，还影响工作和家庭生活。基于文献，对更年期女性外阴萎缩症状的当代管理方法进行了综述。描述了目前治疗更年期女性外阴阴道萎缩的方法。简要分析了现有的口服和阴道用脱氢表雄酮（DHEA）制剂的药理学。介绍了使用DHEA的自身经验。已发现阴道用DHEA对有阴道萎缩症状的更年期女性是一种有效且安全的治疗方法。
