Department of Medicine, University of Illinois at Chicago, Chicago, IL, U.S.A.
Médica Uruguaya, Corporación de Asistencia Médica, Montevideo, Uruguay.
Anticancer Res. 2014 Sep;34(9):5001-6.
Peritoneal angiosarcoma is an extremely rare sarcoma (0.01287% incidence per 100,000) with an aggressive clinical course and a poor prognosis. We herein report a case of a young man with diagnosis of angiosarcoma whose tumor adhering to the inferior wall of his bladder and omentum was initially thought to be rhabdomyosarcoma. His disease state progressively worsened, despite initiation of different types of chemotherapies. Blood was tested for cytokine and soluble receptor levels. Unexpectedly and never previously reported, very high levels of interleukin-6 (IL-6), osteopontin, and prolactin were found. Surprisingly, angiogenic cytokines levels were low. The patient died 5 months after initial presentation. In the present report, we discuss the difficulties in diagnosing this rare sarcoma and possible therapeutic targets, including the IL-6 pathway that may provide more effective ways in controlling this cancer in its metastatic stage.
腹膜血管肉瘤是一种极为罕见的肉瘤（每 10 万人中有 0.01287%的发病率），具有侵袭性临床病程和不良预后。我们在此报告一例年轻男性的血管肉瘤病例，其肿瘤最初被认为是横纹肌肉瘤，附着在膀胱和大网膜的下壁。尽管开始了不同类型的化疗，但他的病情仍逐渐恶化。检测了血液中的细胞因子和可溶性受体水平。出乎意料的是，从未有过报道，发现白细胞介素 6（IL-6）、骨桥蛋白和催乳素水平非常高。令人惊讶的是，血管生成细胞因子水平较低。该患者在初次就诊后 5 个月死亡。在本报告中，我们讨论了诊断这种罕见肉瘤的困难和可能的治疗靶点，包括 IL-6 途径，这可能为控制转移性癌症提供更有效的方法。
