Yu Guohua, Lin Chunhua, Wang Wei, Han Yekun, Qu Guimei, Zhang Tingguo
Department of Pathology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China ; Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shangdong 264000, P.R. China.
Department of Surgery, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shangdong 264000, P.R. China.
Oncol Lett. 2014 Oct;8(4):1595-1598. doi: 10.3892/ol.2014.2384. Epub 2014 Jul 25.
Squamous cell carcinoma is a common malignant tumor of the uterine cervix. The present study reports the case of squamous cell carcinoma of the uterine cervix with osteoclast-like giant cells (OGCs) in an 84-year-old female who had suffered from irregular vaginal bleeding for one month. Colposcopy was performed and a cauliflower-like mass was identified in the front lip of the uterine cervix. Biopsy was then performed, and the tumor was found to be composed of epithelial cell nests, ranging in size. The neoplastic cells exhibited unclear boundaries and eosinophilic cytoplasm. Additionally, the nuclei were atypical and mitosis was observed. Among the epithelial nests, there were numerous OGCs with abundant eosinophilic cytoplasm, as well as multinucleation with bland nuclei. By immunohistochemical staining, the epithelial cells were positive for cytokeratin, while negative for CD68 and vimentin. By contrast, the immunophenotype of the OGCs was the exact opposite. Based on the histological characters, a diagnosis of squamous cell carcinoma of the uterine cervix associated with OGCs was made. Considering the age of the patient, radiotherapy was administered. The patient succumbed to brain metastasis of the tumor after eight months of follow-up.
鳞状细胞癌是子宫颈常见的恶性肿瘤。本研究报告了一例84岁女性子宫颈鳞状细胞癌伴破骨细胞样巨细胞(OGCs)的病例,该患者有一个月的不规则阴道出血病史。进行了阴道镜检查,在子宫颈前唇发现一个菜花状肿物。随后进行活检,发现肿瘤由大小不一的上皮细胞巢组成。肿瘤细胞边界不清,细胞质嗜酸性。此外,细胞核异型,可见有丝分裂。在上皮巢中,有许多细胞质丰富嗜酸性的OGCs,以及多核且核温和的细胞。通过免疫组化染色,上皮细胞细胞角蛋白阳性,而CD68和波形蛋白阴性。相比之下,OGCs的免疫表型正好相反。根据组织学特征,诊断为子宫颈鳞状细胞癌伴OGCs。考虑到患者年龄,给予了放射治疗。随访8个月后,患者死于肿瘤脑转移。